Background:
This Research Topic aims to explore the application of multi-modality tools in studying functional and mechanistic aspects of nervous systems. The nervous systems of different organisms, such as C. elegans, fruit flies, zebrafish, and mice, vary in complexity and redundancy, but with recent advancements in technology, researchers are now able to investigate the nervous systems through multiple modalities, including neurogenetic tools, micro- and mesoscale imaging techniques, electrophysiology, optogenetics, and multiplexed molecular profiling. Additionally, rapid advancements in connectomics and transcriptomics, including single-cell and spatial approaches, have generated extensive datasets for neural investigations. These approaches provide a more comprehensive understanding of the complex neural networks, cellular mechanisms, and functional processes occurring within the nervous system.

Goal:
The primary goal of this Research Topic is to address the need for integrating different modalities to achieve a deeper understanding of nervous system mechanisms. By combining and analyzing data from various techniques, researchers can gain insight into neural connectivity, activity, molecular identity, and behavior in healthy and diseased models. Additionally, this Research Topic aims to explore the development and application of existing multi-modal approaches to provide a comprehensive understanding of the intricacies of the nervous system in both basic and clinical contexts.

Scope and Information for Authors:
This Research Topic welcomes contributions that explore the applications of multi-modality tools and techniques in the study of nervous systems. Authors are encouraged to submit original research articles, reviews, mini-reviews, and methodological papers. Potential topics of interest include, but are not limited to:

- Multi-modal approaches for investigating connectivity, activity, molecular identity, and behavior in nervous systems.
- Development and application of advanced tools and techniques that enable multi-modal interrogations.
- Analysis of local and global neuron activity and behavior using multi-modal approaches.
- Network modeling and hypothesis testing using large datasets generated through multi-modal investigations.
- Molecular and connectomics circuitry identification and mechanistic exploration using multi-modal tools.
- Optogenetic, thermogenetic, and chemogenetic approaches for studying neural function and behavior.

We look forward to receiving high-quality contributions that enhance our understanding of the nervous system through the utilization of multi-modal approaches.

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Frontiers in Molecular Neuroscience

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Impact