The field of neuroendocrinology delves into the complex communication between the brain and internal organs, particularly examining how nutrients modulate this interaction to influence both physical and mental health. Current research emphasizes the bidirectional nature of this relationship: the brain can induce physiological responses—such as salivation or hunger—through sensory cues, while internal organs, in turn, impact brain function via hormonal signals. For example, leptin, secreted by adipocytes in response to high blood glucose levels, induces satiety and a sense of well-being, whereas low blood glucose triggers hunger and the release of glucocorticoids and glucagon to mobilize energy reserves. Despite significant advancements, there are still gaps in understanding the specific mechanisms governing this neuroendocrine communication, particularly regarding the regulatory role of nutrients and their broader implications for health.

This Research Topic aims to deepen understanding of the mechanisms underlying the reciprocal communication between the brain and internal organs, with a focus on how nutrients regulate these processes. Central areas of interest include the brain’s role in controlling the physiological state of internal organs in response to hunger and satiety, the influence of physiological states—such as blood glucose levels—on brain function, especially within the hypothalamus, and the impact of nutrients on neuroendocrine communication affecting both mental and physical health. By addressing these areas, this Research Topic seeks to advance knowledge of the neuroendocrine regulation of feeding behavior and metabolic homeostasis.

To further explore the scope of this Research Topic, we welcome submissions addressing, but not limited to, the following themes:

Taste sensation and cognition
Taste memory and conditional learning
Taste preference and its neural basis
Sensory detection of blood glucose levels in the hypothalamus
Nutrient-driven regulation of the endocrine system
Hypothalamic influence on the autonomic nervous system
Hormonal regulation of feeding behavior
The role of hormones like insulin, glucagon, and leptin within hypothalamic neuronal networks
Motivation and homeostatic control of blood glucose levels

We encourage submissions of original research articles, reviews, mini-reviews, perspectives, and opinion pieces to contribute to this comprehensive exploration of neuroendocrine communication.

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Frontiers in Molecular Neuroscience

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