Drug resistance, whether intrinsic or acquired, is a leading cause of treatment failure in cancer therapy. These drugs, while inhibiting tumor growth and killing cancer cells, also impose evolutionary pressures on these cells. As a result, cells initiate energy transformations to endure these hostile environments, ultimately ensuring their survival. Consequently, investigating the potential mechanisms of deviant energy metabolism has emerged as a novel arena for cancer therapy and drug development.
Energy metabolism is a defining characteristic of cancer, and targeting the energy metabolism of cancer cells has shown promise as a strategic approach for treatment. However, the development of anti-cancer drugs from an energy metabolism perspective is limited. Moreover, the exploration of drug resistance through the lens of energy metabolism is in its initial stages. Often, the administration of certain anti-cancer drugs and the activation of tumor suppressor signaling pathways modify energy metabolism, which is a common occurrence but frequently overlooked. This topic welcomes all studies on energy metabolism, including new drug development, drug resistance in relation to all types of energy metabolism, and innovative viewpoints on the role of energy metabolism in drug therapy.
We welcome submissions of original research papers, reviews, case report, clinical trial, data report, hypothesis & theory, methods, and opinions, including (but not limited to) research on the following sub-themes:
•Insightful reviews exploring the relationship between energy metabolism and drug resistance in cancer therapy.
•Investigations into various types of energy metabolism (e.g., glucose, lipid, amino acid metabolism) and their roles in drug resistance (chemotherapy, targeted therapy, and immunotherapy) within cancer therapy are encouraged.
•Papers unraveling newly discovered compounds connected to energy metabolism in cancer therapy are desired.
•Studies revealing new roles of classic anti-cancer drugs in energy metabolism.
Keywords:
Energy Metabolism; Glucose Starvation, Lipid Metabolism, Cancer Cell Death; Drug Resistance; Chemoresistance; Targeted Therapy; Immunotherapy;
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Drug resistance, whether intrinsic or acquired, is a leading cause of treatment failure in cancer therapy. These drugs, while inhibiting tumor growth and killing cancer cells, also impose evolutionary pressures on these cells. As a result, cells initiate energy transformations to endure these hostile environments, ultimately ensuring their survival. Consequently, investigating the potential mechanisms of deviant energy metabolism has emerged as a novel arena for cancer therapy and drug development.
Energy metabolism is a defining characteristic of cancer, and targeting the energy metabolism of cancer cells has shown promise as a strategic approach for treatment. However, the development of anti-cancer drugs from an energy metabolism perspective is limited. Moreover, the exploration of drug resistance through the lens of energy metabolism is in its initial stages. Often, the administration of certain anti-cancer drugs and the activation of tumor suppressor signaling pathways modify energy metabolism, which is a common occurrence but frequently overlooked. This topic welcomes all studies on energy metabolism, including new drug development, drug resistance in relation to all types of energy metabolism, and innovative viewpoints on the role of energy metabolism in drug therapy.
We welcome submissions of original research papers, reviews, case report, clinical trial, data report, hypothesis & theory, methods, and opinions, including (but not limited to) research on the following sub-themes:
•Insightful reviews exploring the relationship between energy metabolism and drug resistance in cancer therapy.
•Investigations into various types of energy metabolism (e.g., glucose, lipid, amino acid metabolism) and their roles in drug resistance (chemotherapy, targeted therapy, and immunotherapy) within cancer therapy are encouraged.
•Papers unraveling newly discovered compounds connected to energy metabolism in cancer therapy are desired.
•Studies revealing new roles of classic anti-cancer drugs in energy metabolism.
Keywords:
Energy Metabolism; Glucose Starvation, Lipid Metabolism, Cancer Cell Death; Drug Resistance; Chemoresistance; Targeted Therapy; Immunotherapy;
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.