Thousands of people are suffering from viral diseases on a daily basis. As an example, each year approximately 390 million Dengue infections occur in the world, resulting in around 36,000 deaths per year. Similarly, around 460,000 cases of Chikungunya infection have been reported up to the end of November 2023, resulting in over 360 deaths. Several deaths due to West Nile and Zika virus infections have also been reported. For the treatment of these mosquito-borne diseases, it is necessary to design and develop novel drugs that can specifically neutralize different viral proteins of these viruses. However, it is a time-consuming and expensive process that requires coordinated efforts. To promptly deal with these viral diseases, it is imperative to repurpose existing drugs for optimal results. The main purpose of this Research Topic is to collect research ideas that have used the latest medicinal chemistry approaches to repurpose novel existing drugs against different viral proteins of the above mosquito-borne viruses. These drugs could be small molecules, peptides, or peptidomimetics.
It has been demonstrated that drug repurposing is a novel strategy to quickly identify drugs from the pool of existing approved and investigational drugs. However, a thorough investigation of their target binding and measurements of in-vivo potency and toxicity should be undertaken to demonstrate their usefulness for humans. It is also necessary to make structural modifications in the existing drugs, to improve their target binding affinity and reduce toxicity. Hence, systematic approaches are required to identify potential drugs that can be used against the above viruses. As different viral proteins are structurally and functionally similar, repurposed drugs are believed to be specific and potent.
The main objective of this Research Topic is to gather novel strategies and approaches in drug repurposing against viral proteins of different mosquito-borne viral diseases. It encompasses rediscovering the potential impact of existing drugs in inhibiting viral protein activities.
We therefore welcome the submission of manuscripts that directly or indirectly fall under the following subthemes:
1. Docking and molecular-dynamics-based drug repurposing
2. Virtual screening, QSAR modelling, and drug toxicity measurements
3. Artificial intelligence-based drug repurposing
4. In vivo and in vitro studies on drug repurposing
5. Design and synthesis of new drugs derived from the existing drugs
6. Drug toxicity measurements
Critical and focused review articles on drug repurposing methods and applications that advance the field of drug design against different mosquito-borne tropical diseases can also be submitted for consideration.
Keywords:
Antiviral drugs, drug repurposing, tropical diseases, synthesis, modelling
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Thousands of people are suffering from viral diseases on a daily basis. As an example, each year approximately 390 million Dengue infections occur in the world, resulting in around 36,000 deaths per year. Similarly, around 460,000 cases of Chikungunya infection have been reported up to the end of November 2023, resulting in over 360 deaths. Several deaths due to West Nile and Zika virus infections have also been reported. For the treatment of these mosquito-borne diseases, it is necessary to design and develop novel drugs that can specifically neutralize different viral proteins of these viruses. However, it is a time-consuming and expensive process that requires coordinated efforts. To promptly deal with these viral diseases, it is imperative to repurpose existing drugs for optimal results. The main purpose of this Research Topic is to collect research ideas that have used the latest medicinal chemistry approaches to repurpose novel existing drugs against different viral proteins of the above mosquito-borne viruses. These drugs could be small molecules, peptides, or peptidomimetics.
It has been demonstrated that drug repurposing is a novel strategy to quickly identify drugs from the pool of existing approved and investigational drugs. However, a thorough investigation of their target binding and measurements of in-vivo potency and toxicity should be undertaken to demonstrate their usefulness for humans. It is also necessary to make structural modifications in the existing drugs, to improve their target binding affinity and reduce toxicity. Hence, systematic approaches are required to identify potential drugs that can be used against the above viruses. As different viral proteins are structurally and functionally similar, repurposed drugs are believed to be specific and potent.
The main objective of this Research Topic is to gather novel strategies and approaches in drug repurposing against viral proteins of different mosquito-borne viral diseases. It encompasses rediscovering the potential impact of existing drugs in inhibiting viral protein activities.
We therefore welcome the submission of manuscripts that directly or indirectly fall under the following subthemes:
1. Docking and molecular-dynamics-based drug repurposing
2. Virtual screening, QSAR modelling, and drug toxicity measurements
3. Artificial intelligence-based drug repurposing
4. In vivo and in vitro studies on drug repurposing
5. Design and synthesis of new drugs derived from the existing drugs
6. Drug toxicity measurements
Critical and focused review articles on drug repurposing methods and applications that advance the field of drug design against different mosquito-borne tropical diseases can also be submitted for consideration.
Keywords:
Antiviral drugs, drug repurposing, tropical diseases, synthesis, modelling
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.