The discoveries and progress in medicine, biology, and chemistry in the last decades have revolutionized diagnostic and therapeutic methodologies for a large plethora of biomedical applications.

Nanotechnologies represent the main tool to apply these developments and innovations in realistic scenarios, bridging the gap between technological advances and clinical demands, and enabling the translation from the lab to clinical practice. Their ability to improve the capabilities and performance of biomedical devices, together with their high reliability, integrability, and yield make nanotechnology-based solutions the most promising of the next-generation systems in bioengineering and biomedical fields.

The application of nanotechnologies by using different techniques, e.g., optical, electrical, magnetic, and microfluidic methods, and emerging materials, e.g., nanomaterials, quantum dots, and nanostructured substrates, has been demonstrated to improve both sensing and imaging capabilities from the microscale (i.e., cells, tissue, bacteria) to the nanoscale (i.e., proteins, nucleic acids, vesicles, and viruses). The high sensitivity and specificity obtained with nanotechnology-based systems are enabling new studies in the biomedical field completely unexplored before, with evident advantages for the early detection of diseases.

Moreover, the possibility to manipulate the interaction of nanomaterials and biological targets with reliable processes in a controlled environment for the creation of nano-carriers is developing the creation of new drugs with remarkable advantages in therapeutics in personalized nanomedicine with patient-based treatments, with a strong impact in pharmacology and immunology.

These are only a few fields in medicine where nanotechnologies are playing a primary role, but evident advantages have been also obtained in oncology, for the investigation of neurodegenerative and infectious diseases and to tackle heterogeneity in drug resistance.

This research topic aims at investigating and collecting techniques, methods, and solutions applied in biomedical studies based on the use of innovative nanotechnologies. Original research studies based on the following themes are strongly invited to contribute:
-The use of nanodevices to enhance the signal and the detection resolution for sensing and imaging of biological targets with both labeled and label-free methods.
-Novel fabrication techniques for the development of devices and systems to apply in point-of-care systems.
-Design and realization of nanocarriers for drug delivery with novel approaches to improve the delivery efficiency and scalability, and minimize the toxicity.
-Systems based on the combination of multiple physics and techniques, and multiparameter studies to investigate more efficiently the heterogeneity and evolution of diseases, and drug and therapy response.

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Frontiers in Bioengineering and Biotechnology

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