About this Research Topic
It is critical to comprehend the cellular, molecular, and biochemical aspects of cancer cells, which consequently paves the way for innovative therapeutic opportunities in cancer treatment. The organization that cells acquire in 3D models contributes to a better understanding of the tumorigenesis mechanism. 3D cell culture represents an interesting solution because it allows intra-tumor and tumor-stroma contacts, therefore closely resembling a real tumor mass growing in a living organism. Finally, this method provides a useful platform to identify the biological characteristics of tumor cells. Therefore, the goal of this research topic is to offer new insights into cancer using 3D cellular models.
We welcome the submission of Original Research articles, Perspectives, Opinions, Reviews, and Mini Reviews highlighting new advances including but not limited to the following subjects:
• Application of 3D culture model in tumor biology
• Modeling cancer spheroids and organoids
• Use of 3D culture model in drug screening
• Use of 3D culture model for personalized medicine
• Optimization of 3D tumor model for drug discovery research
A full list of accepted article types, including descriptions, can be found at this link.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
Keywords: 3D culture system, modeling cancer spheroids, modeling cancer organoids, patient-derived 3D cancer models, drug discovery, personalized therapy, tumor microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.