About this Research Topic
Vascular systems include systemic system and multiple organ systems. All organ vascular systems share their common features, while each individual organ system has its own characteristics. All vascular systems contain two major types of cells: endothelial and smooth muscle cells. Both lines of cells have many various receptors and binding sites for hormones and endocrine factors, regulating vascular functions. Moreover, vascular cells themselves can produce and release some endocrine factors or endocrine-like factors for systemic homeostasis. Either vascular dysfunction or disordered endocrine systems can induce vascular and endocrine diseases.
The vascular cells play a central role in the regulation of blood flow through continuous modulation of vascular tone, where healthy endothelial and smooth muscle cells are essential for the maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects. Oppositely, vascular cell dysfunction is principally characterized by impaired endothelium-dependent and independent transduction mechanisms related to vascular tone, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that endocrine pathological disorders, including impaired glucose tolerance, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, polycystic ovary syndrome, gestational diabetes, subclinical hypothyroidism, primary hyperparathyroidism, primary aldosteronism, Cushing's syndrome, hypopituitarism, or COVID-19 – related endocrine disorders include notable vascular changes associated with vascular dysfunction.
Our last volume focused on “Endothelial Dysfunction and Endocrine Diseases” and attracted attention from contributors and readers. This new volume expands vascular cells from endothelial cells only to both smooth muscle cells and endothelial cells. We invite potential authors in research of various organ fields to consider a contribution to this volume, focusing on relationships between “Vascular Dysfunction and Endocrine Disorders”.
The goal of this Research Topic is to summarize some of the latest clinical and laboratory findings related to the role of vascular cell dysfunction in aetiology and pathogenesis of different endocrine disorders, as well as existing and novel therapeutic possibilities for modulating and improving vascular dysfunction in treatment of endocrine diseases or complications. This is substantiated with still increasing data pointing out that pharmacological approach in improving or reversing vascular dysfunction was shown to be beneficial in clinical trials aimed to this scientific problem.
Specific themes:
- aetiology of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- contribution of vascular endothelial or/and smooth muscle cells in pathogenesis of endocrine disorders
- biomarkers of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- non-invasive clinical protocols for detection of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- vascular endothelial or/and smooth muscle cell dysfunction as a consequence of endocrine disorders
- COVID-19 and vascular endothelial or/and smooth muscle cell dysfunction interplay in endocrine disorders
- treatment options for improvement or reversal of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- prevention possibilities against vascular endothelial or/and smooth muscle cell dysfunction occurrence in endocrine disorders
Type of papers:
- Original research papers
- Review papers
The vascular cells play a central role in the regulation of blood flow through continuous modulation of vascular tone, where healthy endothelial and smooth muscle cells are essential for the maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects. Oppositely, vascular cell dysfunction is principally characterized by impaired endothelium-dependent and independent transduction mechanisms related to vascular tone, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that endocrine pathological disorders, including impaired glucose tolerance, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, polycystic ovary syndrome, gestational diabetes, subclinical hypothyroidism, primary hyperparathyroidism, primary aldosteronism, Cushing's syndrome, hypopituitarism, or COVID-19 – related endocrine disorders include notable vascular changes associated with vascular dysfunction.
Our last volume focused on “Endothelial Dysfunction and Endocrine Diseases” and attracted attention from contributors and readers. This new volume expands vascular cells from endothelial cells only to both smooth muscle cells and endothelial cells. We invite potential authors in research of various organ fields to consider a contribution to this volume, focusing on relationships between “Vascular Dysfunction and Endocrine Disorders”.
The goal of this Research Topic is to summarize some of the latest clinical and laboratory findings related to the role of vascular cell dysfunction in aetiology and pathogenesis of different endocrine disorders, as well as existing and novel therapeutic possibilities for modulating and improving vascular dysfunction in treatment of endocrine diseases or complications. This is substantiated with still increasing data pointing out that pharmacological approach in improving or reversing vascular dysfunction was shown to be beneficial in clinical trials aimed to this scientific problem.
Specific themes:
- aetiology of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- contribution of vascular endothelial or/and smooth muscle cells in pathogenesis of endocrine disorders
- biomarkers of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- non-invasive clinical protocols for detection of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- vascular endothelial or/and smooth muscle cell dysfunction as a consequence of endocrine disorders
- COVID-19 and vascular endothelial or/and smooth muscle cell dysfunction interplay in endocrine disorders
- treatment options for improvement or reversal of vascular endothelial or/and smooth muscle cell dysfunction in endocrine disorders
- prevention possibilities against vascular endothelial or/and smooth muscle cell dysfunction occurrence in endocrine disorders
Type of papers:
- Original research papers
- Review papers
Keywords: Vascular endothelium cells, vascular smooth muscle cells, vascular dysfunction, endocrine disorders
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