The multifaceted exchange between microbial networks and their hosts has long enthralled researchers across assorted diverse scientific realms. Recent strides in microbiome-based metabolomics have enlightened the significant effect of microbial metabolites on both human wellbeing and the more broader environment. We aim to investigate the multi-layered scene of microbiome-based metabolomics, projecting a wide net over different microbial players and their metabolites. Delving into the intricacies of microbial collaborations, we seek to redefine the far-reaching implications of the metabolites produced by bacteria on both human systems and the global microbial ecology. Significantly actinobacteria, ubiquitous microorganisms found in a myriad of environments, stand out as prolific producers of diverse bioactive metabolites. Their adaptable metabolic capacities essentially add to the microbial variety inside the human microbiome as well as the more extensive ecological microbiota. We can study the myriad metabolites synthesized by actinobacteria, ranging from antimicrobial compounds to enzymes and other bioactive molecules, shaping the intricate tapestry of microbial interactions. The human microbiome, overflowing with trillions of microorganisms, significantly impacts physiological capabilities. Bacterial metabolites, including antimicrobial and immunomodulatory compounds, add to the sensitive equilibrium inside the microbiome, impacting host wellbeing and infection weakness. The need to investigate the positive effects of bacterial metabolites in keeping up with homeostasis, and forestalling pathogenic contaminations, as well as the role of modulating host immune responses is lacking. Adding to bridging the molecular aspects towards the role of metabolites and functional aspects of the bacteria as its own as well as a biome is required.

The consortia of microscopic organisms likewise assume an essential part in molding the natural microbiome. Their metabolites add to natural cycles, like supplement cycling and natural matter decay. Research in not only the positive aspects of bacterial metabolites in ecological balance but also their potential negative impacts, such as the production of secondary metabolites with ecological consequences as well as the emergence of antibiotic resistance in environmental microbial communities is necessary.

The advent of high-throughput metabolomic strategies has revolutionized our capacity to profile and break down the huge range of metabolites related to assorted microbial networks. Through this work we intend to investigate how metabolomics has changed how we might interpret microbial networks, giving bits of knowledge into the useful elements of microbiomes and their effect on human wellbeing as well as the environment. We aim to delve into and discuss the capacity of microbial metabolites, including those from actinobacteria, as remedial specialists, accentuating their part in drug improvement and therapeutic interventions.

All in all, this collection offers to implicate an exhaustive investigation of the microbiome-based metabolomics revolution, enveloping different microbial contributors by unwinding the complexities of microbial collaborations. This collection welcomes themes on, but not limited to:

• Role of microbiome in human functional systems.

• Metabolites with beneficial as well as hindering effects against biomedical aspects.

• Metabolomics in the field of microbiome.

• Molecular and genetic aspects of metabolites.

• Role of cell-to-cell communication relating to production of metabolites.

• Pathways employed for the exhibition of biomedical characteristics as well as metabolite production.

• Personalized medicine and microbiome

• Microbiome and aging

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Frontiers in Cellular and Infection Microbiology

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