About this Research Topic
Concerns surrounding the pervasive presence of environmental endocrine disrupting chemicals (EDCs) and their potential impact on human health have garnered increasing attention. EDCs, prevalent in various substances and products, are known to interfere with the endocrine system, contributing to a spectrum of adverse health outcomes.
There is a widely spread interaction between dietary factors and EDCs on human health. The interaction between dietary factors and exposure to environmental EDCs can be mainly reflected in three aspects. First, diet is an important source of some specific types of EDCs. For example, fish intake is a key role of exposure to per-and polyfluoroalkyl substances (PFAS). Second, there may be some bidirectional association between blood concentrations of some nutrients and EDCs. For example, intake of some nutrients, such as dietary fiber, could reduce blood concentrations of EDCs, and exposure to EDCs may also affect the metabolism of some nutrients such as vitamin D. Third, some nutrients intake, like total fat, could enhance the adverse effects of EDCs. Also, some nutrient intake like vitamin D may also could mitigate the adverse effects of EDCs.
Due the widespread use of EDCs, it is difficult to reduce the population's exposure to EDCs in the short term. EDCs have been widely found to cause adverse effects on the body through oxidative stress and inflammatory pathways. Healthful dietary patterns may provide protection against the effect of exposure to EDCs. For example, an anti-inflammatory diet with a high intake of fresh fruits and green leafy vegetables can reduce the effect of PFAS or bisphenol A on human health. Possible mechanisms may include modulation of immunity, gut microbiota, and lipid accumulation. However, current studies are still mainly limited and mainly focus on specific foods or nutrients. There is a lack of assessment regarding on the interaction between overall dietary status and endocrine-disrupting chemicals (EDCs), as well as insufficient research on population thresholds and the mechanisms involved in the interaction between dietary pattern and EDCs.
This research topic aims to investigate the relationship between dietary factors and environmental endocrine disrupting chemicals (EDCs), specifically to evaluate the impact of dietary patterns, like the anti-inflammatory diet (such as high intake of fresh fruit and leafy green)and dietary antioxidant on adverse health outcomes resulting from EDC exposure. We further seek to explore the protective or enhancive properties of distinct dietary factors (like total fat or vitamin D intake), clarify mechanistic foundations, conduct a threshold analysis to identify protective capabilities of specific nutrients and antioxidants intakes, and investigate the influence of dietary patterns on blood or urine concentrations of EDCs. This comprehensive approach strives to advance our understanding of preventive strategies and mechanisms to mitigate the adverse health effects associated with environmental EDC exposure.
We welcome submissions of (original research, systematic Review, Clinical Trial, Case Report) related to but not limited to the following aspects:
● Evaluate the impact of dietary factors, as quantified by dietary scores such as the dietary inflammatory index (DII) and composite dietary antioxidant index (CDAI), on the modulation of adverse health outcomes resulting from exposure to EDCs.
● Examine the protecting properties of distinct dietary factors in mitigating the adverse health outcomes linked to exposure to environmental EDCs via analysis of population-based investigations and animal studies.
● Clarify the mechanistic foundations through which specific dietary or nutritional elements either trigger or alleviate detrimental health effects resulting from exposure to environmental EDCs.
● Conduct a threshold analysis to identify the protective capability of dietary intakes, such as antioxidants, in alleviating the adverse effects induced by exposure to environmental EDCs.
● Investigate the impact of dietary intake of certain nutrients on the levels of blood or urine concentrations of EDCs, exploring potential causal relationships underpinning these observed alterations.
● Assess the protective role of specific nutrients or diets in populations with high EDC exposure in population-based intervention.
● Explore the interaction between multiple nutrients on the adverse effects of EDCs.
There is a widely spread interaction between dietary factors and EDCs on human health. The interaction between dietary factors and exposure to environmental EDCs can be mainly reflected in three aspects. First, diet is an important source of some specific types of EDCs. For example, fish intake is a key role of exposure to per-and polyfluoroalkyl substances (PFAS). Second, there may be some bidirectional association between blood concentrations of some nutrients and EDCs. For example, intake of some nutrients, such as dietary fiber, could reduce blood concentrations of EDCs, and exposure to EDCs may also affect the metabolism of some nutrients such as vitamin D. Third, some nutrients intake, like total fat, could enhance the adverse effects of EDCs. Also, some nutrient intake like vitamin D may also could mitigate the adverse effects of EDCs.
Due the widespread use of EDCs, it is difficult to reduce the population's exposure to EDCs in the short term. EDCs have been widely found to cause adverse effects on the body through oxidative stress and inflammatory pathways. Healthful dietary patterns may provide protection against the effect of exposure to EDCs. For example, an anti-inflammatory diet with a high intake of fresh fruits and green leafy vegetables can reduce the effect of PFAS or bisphenol A on human health. Possible mechanisms may include modulation of immunity, gut microbiota, and lipid accumulation. However, current studies are still mainly limited and mainly focus on specific foods or nutrients. There is a lack of assessment regarding on the interaction between overall dietary status and endocrine-disrupting chemicals (EDCs), as well as insufficient research on population thresholds and the mechanisms involved in the interaction between dietary pattern and EDCs.
This research topic aims to investigate the relationship between dietary factors and environmental endocrine disrupting chemicals (EDCs), specifically to evaluate the impact of dietary patterns, like the anti-inflammatory diet (such as high intake of fresh fruit and leafy green)and dietary antioxidant on adverse health outcomes resulting from EDC exposure. We further seek to explore the protective or enhancive properties of distinct dietary factors (like total fat or vitamin D intake), clarify mechanistic foundations, conduct a threshold analysis to identify protective capabilities of specific nutrients and antioxidants intakes, and investigate the influence of dietary patterns on blood or urine concentrations of EDCs. This comprehensive approach strives to advance our understanding of preventive strategies and mechanisms to mitigate the adverse health effects associated with environmental EDC exposure.
We welcome submissions of (original research, systematic Review, Clinical Trial, Case Report) related to but not limited to the following aspects:
● Evaluate the impact of dietary factors, as quantified by dietary scores such as the dietary inflammatory index (DII) and composite dietary antioxidant index (CDAI), on the modulation of adverse health outcomes resulting from exposure to EDCs.
● Examine the protecting properties of distinct dietary factors in mitigating the adverse health outcomes linked to exposure to environmental EDCs via analysis of population-based investigations and animal studies.
● Clarify the mechanistic foundations through which specific dietary or nutritional elements either trigger or alleviate detrimental health effects resulting from exposure to environmental EDCs.
● Conduct a threshold analysis to identify the protective capability of dietary intakes, such as antioxidants, in alleviating the adverse effects induced by exposure to environmental EDCs.
● Investigate the impact of dietary intake of certain nutrients on the levels of blood or urine concentrations of EDCs, exploring potential causal relationships underpinning these observed alterations.
● Assess the protective role of specific nutrients or diets in populations with high EDC exposure in population-based intervention.
● Explore the interaction between multiple nutrients on the adverse effects of EDCs.
Keywords: endocrine disrupting chemicals, nutrients, dietary antioxidants, Interaction, dietary inflammatory index, composite dietary antioxidant index
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