About this Research Topic
Skull-base tumors, a subset of neoplasms, pose a unique challenge in oncology due to their intricate location at the interface of the brain and the skull-base. These tumors can arise from various cell types, including those of the brain, nerves, bones, or surrounding tissues, making their classification diverse and complex. Given their proximity to critical structures such as the cranial nerves, major blood vessels, and vital sensory organs, skull-base tumors often present with a spectrum of clinical manifestations, including neurological deficits and sensory disturbances. The intricacies of their anatomical location make surgical resection challenging, necessitating a multidisciplinary approach for optimal management. Advances in imaging, surgical techniques, radiation therapy, and systemic treatments have significantly improved diagnostic accuracy and therapeutic outcomes. This special issue delves into the evolving landscape of skull-base tumor research, aiming to enhance our understanding and refine the multidisciplinary strategies essential for effectively tackling these intricate malignancies. This research topic will focus on primary intracranial (extra- and intraaxial CNS tumours) primary extracranial tumours that involve skull-base (e.g., sinonasal and middle ear tumours) and secondary tumours (i.e., metastasis)
This research topic is designed to provide a platform for researchers, clinicians, and experts from various disciplines to share their insights and contribute to the evolving landscape of skull-base cancer management. The focus will be on multidisciplinary approaches that integrate surgery, radiation therapy, medical oncology, imaging, and other allied specialties to optimize patient outcomes.
1. Surgical Innovations: Explore cutting-edge surgical techniques and technologies that enhance precision and minimize morbidity in skull-base tumor resections. Contributions on endoscopic approaches, robotic surgery, and advancements in neurosurgical interventions are encouraged.
2. Radiation Therapy Strategies:Investigate the latest developments in radiation therapy modalities, including proton therapy, stereotactic radiosurgery, and novel fractionation schemes, with a specific emphasis on their application in skull-base cancer treatment.
3. Medical Oncology Advancements:Address the role of systemic therapies, including targeted therapies and immunotherapies, in the multidisciplinary management of skull-base tumours. Highlight personalized treatment approaches based on molecular and genetic profiling.
4. Imaging and Diagnostic Modalities:Discuss advancements in imaging techniques, such as MRI, CT, and PET-CT, for accurate diagnosis, preoperative planning, and post-treatment surveillance of skull-base tumors. Explore the integration of artificial intelligence in image analysis.
5. Multidisciplinary Collaboration: Emphasize the importance of collaborative efforts among various specialties, including neurosurgery, otolaryngology, radiation oncology, medical oncology, and radiology, in providing comprehensive care for patients with skull-base tumors.
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
This research topic is designed to provide a platform for researchers, clinicians, and experts from various disciplines to share their insights and contribute to the evolving landscape of skull-base cancer management. The focus will be on multidisciplinary approaches that integrate surgery, radiation therapy, medical oncology, imaging, and other allied specialties to optimize patient outcomes.
1. Surgical Innovations: Explore cutting-edge surgical techniques and technologies that enhance precision and minimize morbidity in skull-base tumor resections. Contributions on endoscopic approaches, robotic surgery, and advancements in neurosurgical interventions are encouraged.
2. Radiation Therapy Strategies:Investigate the latest developments in radiation therapy modalities, including proton therapy, stereotactic radiosurgery, and novel fractionation schemes, with a specific emphasis on their application in skull-base cancer treatment.
3. Medical Oncology Advancements:Address the role of systemic therapies, including targeted therapies and immunotherapies, in the multidisciplinary management of skull-base tumours. Highlight personalized treatment approaches based on molecular and genetic profiling.
4. Imaging and Diagnostic Modalities:Discuss advancements in imaging techniques, such as MRI, CT, and PET-CT, for accurate diagnosis, preoperative planning, and post-treatment surveillance of skull-base tumors. Explore the integration of artificial intelligence in image analysis.
5. Multidisciplinary Collaboration: Emphasize the importance of collaborative efforts among various specialties, including neurosurgery, otolaryngology, radiation oncology, medical oncology, and radiology, in providing comprehensive care for patients with skull-base tumors.
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
Keywords: Skull base neoplasm, carcinoma, personalized medicine, paranasal sinus, Central Nervous System Neoplasms, Cranial Nerve Disorders, Neuroendoscopy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
