Sepsis is one of the most common critical illnesses in clinical practice, mainly due to a storm of inflammatory factors caused by various infectious factors that involve the failure of multiple organs in the body. With its rapid onset, long course, and high mortality rate, sepsis poses a serious threat to human health and has aroused wide concern in the medical research community. However, the pathophysiological process of multi-organ dysfunction induced by sepsis has not been fully elucidated. After many years of exploration, numbers of intricate pathogenesis have been studied, while research in immunology is one of the hot spots.

It is well known that various immune cells comprise the immune system, and macrophages play central roles in immunity against microbes and contribute to a wide array of pathologies. The activation processes and functions of macrophages have attracted considerable attention from life scientists. As the main force for fighting infection, the role that macrophages play in sepsis is notable. However, the immunological events of macrophages in the course of sepsis remain to be further investigated.

Here, we aim to elucidate the role of macrophages in different organs in the context of sepsis. We welcome submissions of original research articles, reviews, and mini-reviews that cover, but are not limited to, the following topics:
1. The relationship between different modes of macrophage death and organ-specific damage in sepsis, such as pyroptosis, autophagy, iron death, etc.
2. The role of organ-specific macrophage dysfunction in the sepsis process.
3. Exploration of therapeutic interventions targeting macrophage-related signaling pathways.
4. The effect of extracellular vesicles on macrophage function, including exosomes, OMV.
5. The timeline and spaceline of immunological events in macrophages in sepsis.
6. The role of intestinal microbes and their metabolites in dialogue with macrophages in the development of sepsis.
7. Inter-organ dialogue in the body during sepsis.

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Frontiers in Immunology

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