Infectious diseases continue to pose significant challenges to global healthcare systems, despite advancements in medical sciences and public health standards. At the forefront of these challenges is the issue of co-infections, where simultaneous infections by multiple pathogens exacerbate the healthcare burden. Co-infections can complicate diagnosis, treatment, and management, leading to increased morbidity and mortality. For example, seasonal influenza, typically a moderate illness, can predispose individuals to additional infections, while HIV/AIDS increases susceptibility to opportunistic infections from various pathogens. Current research is focused on unraveling the complex interactions between co-infecting pathogens and their hosts. However, there remains a substantial gap in understanding the underlying mechanisms of these interactions and how they can be effectively managed. This research topic seeks to address these gaps by exploring the multifaceted nature of co-infections and the challenges they present.

This Research Topic aims to elucidate the complexities of co-infections, focusing on the interactions between multiple pathogens and their hosts, and to explore innovative management strategies. The primary objectives include understanding the molecular and immunological mechanisms of pathogen interactions, examining host-pathogen dynamics, and addressing the challenges of antimicrobial resistance and diagnostics in co-infections. By investigating these areas, the research aims to develop novel approaches for the effective management and treatment of co-infections, ultimately reducing their impact on global health.

To gather further insights into the complexities and management of multifaceted co-infections, we welcome articles addressing, but not limited to, the following themes:
- The molecular and immunological mechanisms responsible for interactions between various pathogens during co-infections.
- Understanding host-pathogen interaction during co-infection.
- Antimicrobial resistance and diagnostic challenges in co-infection.
- Modern treatment strategies to combat co-infection.
- Clinical studies of co-infection.
- The development of novel approaches or techniques for managing co-infections.

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Frontiers in Immunology

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