Clinical Management of Huntington Disease: Current Strategies and Future Directions

Huntington Disease (HD) is a devastating neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms, ultimately leading to disability and premature death. It is caused by CAG trinucleotide repeats expansion in the huntingtin gene (HTT), resulting in the accumulation of toxic protein aggregates in the brain. Despite extensive research, effective disease-modifying treatments for HD are still lacking. Therefore, there is an urgent need to explore the clinical management strategies for HD, focusing on enhancing patients’ quality of life and improving disease outcomes.

The goal of this Research Topic is to provide a platform to show case research and comprehensive overview of the clinical management of HD, addressing both current strategies and future directions. We aim to identify the challenges in clinical practice, highlight recent advancements, and foster interdisciplinary collaborations to accelerate therapeutic development. By bringing together researchers, clinicians, and experts in related fields, we aim to contribute to the improved treatment and care of individuals affected by HD.

This Research Topic welcomes original research articles, reviews, and perspectives that explore various aspects of the clinical management of HD. Specific themes to be addressed may include, but are not limited to:
• Pharmacological interventions and novel therapeutic targets
• Clinical trials and emerging therapies
• Symptomatic management approaches for motor, cognitive, and psychiatric symptoms
• Multidisciplinary care models and integrated healthcare strategies including the roles of clinical geneticists, genetic counsellors and social workers
• Role of patient support groups in rare diseases
• Impact of virtual care in neurodegenerative diseases
• Predictive biomarkers, disease monitoring, and personalized medicine approaches
• Modifier genes for HD
• Pharmacogenomic markers for psychiatric medications used in HD
• Mental health support and interventions for caregivers
• Ethical considerations and patient perspectives in clinical management
• Management guidelines
We encourage authors to contribute evidence-based studies, innovative approaches, and comprehensive literature reviews that elucidate the current challenges, propose novel strategies, and shed light on the future directions in the clinical management of Huntington Disease.

Keywords: Huntington Disease, clinical management, therapeutic interventions, neurodegenerative disorder, psychiatry, chorea

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.