About this Research Topic
Myeloid cells, such as monocytes, macrophages, and dendritic cells (DC), are crucial scavengers balancing processes of tissue homeostasis versus immunity. Various subsets of myeloid cells have been described across tissues, including subsets specific to distinct parts of the gastrointestinal tract. Each of these myeloid cell subsets fulfils crucial roles during tissue maintenance, disease pathology and tissue regeneration. However, these functions differ between individual myeloid cell subsets, the tissue niches they patrol or reside in, between fetal and adult tissues and, of course, between types of inflammation. In the gastric system, these can range from autoimmunity to infections (for example, with Helicobacter pylori) to cancers of the gastric system and related tissues.
This Research Topic aims to further our understanding of the functional diversity of myeloid cell subsets within the gastrointestinal tract. To date, our knowledge of the functional specialization of myeloid cell populations in the gastric tract is incomplete, especially in the context of inflammation. It is crucial to understand which populations and/or subsets of myeloid cells contribute to pathology versus recovery in distinct gastric diseases. Combining new discoveries, e.g. facilitated by novel spatial and sequencing technologies, and the collective knowledge of myeloid cell functions during gastric inflammation across different gastric niches and diseases should aid in identifying new therapy targets and approaches that take the entire gastric system into account.
We would like authors to contribute to the following themes:
- Differentiation and function of gastric myeloid subsets.
- Roles of myeloid subsets in gastric cancers.
- Roles of myeloid subsets in autoimmune disorders of the gastric system.
- Roles of myeloid subsets during gastric infection (e.g. Helicobacter pylori infection and others).
- Interaction of gastric microbiome and gastric myeloid subsets.
- Myeloid subsets and immune functions in fetal versus adult.
This Research Topic aims to further our understanding of the functional diversity of myeloid cell subsets within the gastrointestinal tract. To date, our knowledge of the functional specialization of myeloid cell populations in the gastric tract is incomplete, especially in the context of inflammation. It is crucial to understand which populations and/or subsets of myeloid cells contribute to pathology versus recovery in distinct gastric diseases. Combining new discoveries, e.g. facilitated by novel spatial and sequencing technologies, and the collective knowledge of myeloid cell functions during gastric inflammation across different gastric niches and diseases should aid in identifying new therapy targets and approaches that take the entire gastric system into account.
We would like authors to contribute to the following themes:
- Differentiation and function of gastric myeloid subsets.
- Roles of myeloid subsets in gastric cancers.
- Roles of myeloid subsets in autoimmune disorders of the gastric system.
- Roles of myeloid subsets during gastric infection (e.g. Helicobacter pylori infection and others).
- Interaction of gastric microbiome and gastric myeloid subsets.
- Myeloid subsets and immune functions in fetal versus adult.
Keywords: myeloid cells, cancer, autoimmune disease, infection, fetal, microbial
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
