About this Research Topic
Maintaining tissue homeostasis requires a balance between cell death and survival. Dysregulation of these processes can lead to diseases, including inflammation and cancer. Cell death has traditionally been classified as apoptosis or necrosis. However, emerging evidence suggests that cell death can occur through diverse patterns, such as necroptosis, pyroptosis, ferroptosis and autophagy-dependent cell-death. Understanding the mechanisms and regulation of cell-death patterns is crucial for developing effective therapeutic strategies.
The traditional view of cell death as a binary process (apoptosis or necrosis) is oversimplified and does not fully capture the complexity of cell-death pathways. This limitation hinders the development of targeted therapies for diseases characterized by dysregulated cell death, such as inflammation and cancer. Therefore, it is necessary to explore and characterize the various patterns of cell death and their roles in the pathogenesis of diseases.
The research objectives are to investigate the molecular mechanisms that underlie various cell-death patterns in inflammation and cancer, identify the key regulators and signaling pathways involved in modulating cell-death patterns, explore the crosstalk between different cell-death pathways and their impact on disease progression, and develop novel therapeutic strategies that target specific cell-death patterns for the treatment of inflammation and cancer.
Contributors are encouraged to address the following themes:
1. Characterization of diverse cell-death patterns and their molecular mechanisms.
2. Role of cell-death patterns in inflammation and cancer pathogenesis.
3. Crosstalk between different cell-death pathways and their implications in disease progression.
4. Identification of novel therapeutic targets and strategies for modulating specific cell-death patterns.
5. Evaluation of the efficacy and safety of emerging treatment approaches targeting cell-death pathways.
The types of manuscripts of interest include original research articles that investigate the molecular mechanisms and regulation of diverse cell-death patterns in inflammation and cancer. Review articles should provide comprehensive overviews of the current understanding of cell-death patterns and their roles in disease pathogenesis.
The traditional view of cell death as a binary process (apoptosis or necrosis) is oversimplified and does not fully capture the complexity of cell-death pathways. This limitation hinders the development of targeted therapies for diseases characterized by dysregulated cell death, such as inflammation and cancer. Therefore, it is necessary to explore and characterize the various patterns of cell death and their roles in the pathogenesis of diseases.
The research objectives are to investigate the molecular mechanisms that underlie various cell-death patterns in inflammation and cancer, identify the key regulators and signaling pathways involved in modulating cell-death patterns, explore the crosstalk between different cell-death pathways and their impact on disease progression, and develop novel therapeutic strategies that target specific cell-death patterns for the treatment of inflammation and cancer.
Contributors are encouraged to address the following themes:
1. Characterization of diverse cell-death patterns and their molecular mechanisms.
2. Role of cell-death patterns in inflammation and cancer pathogenesis.
3. Crosstalk between different cell-death pathways and their implications in disease progression.
4. Identification of novel therapeutic targets and strategies for modulating specific cell-death patterns.
5. Evaluation of the efficacy and safety of emerging treatment approaches targeting cell-death pathways.
The types of manuscripts of interest include original research articles that investigate the molecular mechanisms and regulation of diverse cell-death patterns in inflammation and cancer. Review articles should provide comprehensive overviews of the current understanding of cell-death patterns and their roles in disease pathogenesis.
Keywords: cell death, cell survival, treatment strategy, inflammation, cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
