About this Research Topic
Kidney function decline (KFD) continues to be a global health problem in patients undergoing aortic vascular procedures. KFD spans both the acute and long term stages of patient care. The etiology of KFD is hypothesized to be multi-factorial and to vary by the aortic repair approach. Some of the proposed mechanisms are ischemia reperfusion injury, alteration renal blood flow, contrast-induced, intraoperative reduction in renal blood flow due to hypoperfusion, embolic migration of atherosclerotic plaques to renal microvasculature and inflammation-based phenomena. Added to the complexity the various definitions and classification that have been historically used to assess, define and prognosticate renal dysfunction in this population. Over the years, multiple risk prediction models have been employed to risk stratify patients undergoing these procedures and to predict adverse outcomes. Additionally, renal protective clinical protocols have been designed to protect and prevent the occurrence of KFD in this population, mostly in an institution dependent manner, with variable success. Towards this end, there is an interest to study kidney dysfunction in this population diagnostically, therapeutically and prognostically.
The goal of the current Research Topic is to update the public on KFD in the vascular surgical population. Compared to the cardiac surgical population, the vascular surgical population has received less attention to KFD. This results from the relatively smaller volume of procedures performed in this population compared to the cardiac surgical population, the false sense of security imposed by the advent of minimally invasive procedures, lack of availability of long term data of follow up national databases and the relatively lack of focus on kidney organ dysfunction compared to other outcomes pertinent to the procedural approach. Therefore, this project is theorized to inform the scientific community on proposed mechanisms of KFD, updated risk stratification in this population, current diagnostic modalities used and treatment options to address this problem both at acute and delayed phases.
Researchers are encouraged to submit Original Research, Clinical Trials and Systematic Review articles on topics including, but not limited to:
• Basic science studies that address novel diagnostic modalities such as biomarkers, exosomes and imaging
• Basic science mechanistic studies in animal models both small and large
• Translational studies that discuss the application of basic science in a clinical setting
• Clinical diagnostic, prognostic and therapeutic studies that discuss prediction models, clinical biomarkers, and preventive algorithms
• Population studies that demonstrate differences in the population propensities of KFD and access to care such as dialysis and clinical counseling such as females, elderly, socially disadvantaged communities
• Quality initiatives that improve the care of this population in acute settings, and in the community such as reduction of readmissions, employment of bundle therapies and reduction of lengths of hospital and intensive care unit stays
The goal of the current Research Topic is to update the public on KFD in the vascular surgical population. Compared to the cardiac surgical population, the vascular surgical population has received less attention to KFD. This results from the relatively smaller volume of procedures performed in this population compared to the cardiac surgical population, the false sense of security imposed by the advent of minimally invasive procedures, lack of availability of long term data of follow up national databases and the relatively lack of focus on kidney organ dysfunction compared to other outcomes pertinent to the procedural approach. Therefore, this project is theorized to inform the scientific community on proposed mechanisms of KFD, updated risk stratification in this population, current diagnostic modalities used and treatment options to address this problem both at acute and delayed phases.
Researchers are encouraged to submit Original Research, Clinical Trials and Systematic Review articles on topics including, but not limited to:
• Basic science studies that address novel diagnostic modalities such as biomarkers, exosomes and imaging
• Basic science mechanistic studies in animal models both small and large
• Translational studies that discuss the application of basic science in a clinical setting
• Clinical diagnostic, prognostic and therapeutic studies that discuss prediction models, clinical biomarkers, and preventive algorithms
• Population studies that demonstrate differences in the population propensities of KFD and access to care such as dialysis and clinical counseling such as females, elderly, socially disadvantaged communities
• Quality initiatives that improve the care of this population in acute settings, and in the community such as reduction of readmissions, employment of bundle therapies and reduction of lengths of hospital and intensive care unit stays
Keywords: Acute Kidney Injury, Aortic Aneurysm, TEVAR, EVAR, cross clamping, chronic kidney disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
