About this Research Topic
Cancer is a leading cause of mortality worldwide. By 2040, it is expected the number of deaths will rise from ~10 to 16 million. Despite recent advances in the fight against cancer, progress in prevention, diagnosis, prognosis, treatment, and survival has been unequal around the globe. Health equity remains a challenge as disparities in cancer outcomes vary within and across high-, middle, and low-income countries due to differences in risk factors. Biological risk factors interact with various social, economic, environmental, and behavioral determinants of health. Precision medicine is an approach that takes into account individual differences in patients’ biology, environments, and lifestyles. Precision medicine also includes precision prevention, which involves having a comprehensive understanding of cancer causes to develop new interventions that reduce risk in individuals, populations, communities, and countries.
In order for everyone to benefit from the promise of precision medicine, approaches are necessary to tailor prevention and treatment efforts to global subpopulations who differ in cancer susceptibility or response to specific therapies. The goal of this research topic is to highlight new molecular targets that can help deliver the right interventions/treatments to the right people at the right time, with the hope of translating these findings to individuals around the world. Innovative research approaches can utilize both classic and contemporary methods to address novel questions about “why” and “how” global cancer inequalities persist. In particular, omic tools, techniques, and research strategies (such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, and others) offer high-throughput methods to discover biological mechanisms that underlie cancer-associated disease patterns in every population. Most importantly, this collection provides opportunities to leverage integrated biological, environmental, and behavioral data to close cancer outcome gaps around the world.
This research topic aims to highlight cutting-edge basic, clinical, and translational research that advances global oncology and aims to promote cancer health equity. We welcome the submission of original research, any type of review, and brief research reports, including but not limited to, these topics:
-Types of cancers with disproportionate geographic burden in certain regions of the world
-Differences in tumor biology amongst subpopulations inside and outside of particular countries
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
In order for everyone to benefit from the promise of precision medicine, approaches are necessary to tailor prevention and treatment efforts to global subpopulations who differ in cancer susceptibility or response to specific therapies. The goal of this research topic is to highlight new molecular targets that can help deliver the right interventions/treatments to the right people at the right time, with the hope of translating these findings to individuals around the world. Innovative research approaches can utilize both classic and contemporary methods to address novel questions about “why” and “how” global cancer inequalities persist. In particular, omic tools, techniques, and research strategies (such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, and others) offer high-throughput methods to discover biological mechanisms that underlie cancer-associated disease patterns in every population. Most importantly, this collection provides opportunities to leverage integrated biological, environmental, and behavioral data to close cancer outcome gaps around the world.
This research topic aims to highlight cutting-edge basic, clinical, and translational research that advances global oncology and aims to promote cancer health equity. We welcome the submission of original research, any type of review, and brief research reports, including but not limited to, these topics:
-Types of cancers with disproportionate geographic burden in certain regions of the world
-Differences in tumor biology amongst subpopulations inside and outside of particular countries
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
Keywords: Global oncology, precision medicine, precision prevention, health equity, health disparities, molecular epidemiology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
