About this Research Topic
However, despite these remarkable opportunities, solid tumor immunotherapy faces certain challenges. One of the major hurdles is the tumor microenvironment, which often presents an immunosuppressive milieu. Head and neck cancers create an immunosuppressive microenvironment by expressing inhibitory molecules, recruiting regulatory immune cells, and inducing immune checkpoints. These factors can impede the effectiveness of immunotherapy by limiting immune response activation against the tumor. Overcoming these challenges requires innovative strategies such as combination therapies, personalized medicine approaches, and targeted delivery methods to enhance the immune response and optimize treatment outcomes. Additionally, identifying appropriate predictive biomarkers to select patients most likely to respond to immunotherapy remains an ongoing area of research.
This Research Topic seeks to provide a comprehensive overview of the new era of solid tumor immunotherapy. It aims to advance our understanding of solid tumor immunotherapy, foster collaborations, and inspire novel research directions.
In this Research Topic, we welcome original research articles, reviews, and perspective articles that explore various themes related to solid tumor immunotherapy. These themes include, but are not limited to:
- The Relationship Between Tumor Microenvironment and Immune Checkpoint Inhibitors in Head and Neck Cancers
- Biomarkers for Patient Selection and Response Prediction in the treatment of Immune Checkpoint Inhibitors in Head and Neck Cancers.
- Combination Approaches of Immune Checkpoint Inhibitors with Other Treatment Modalities
- Predictive biomarkers for irAEs in Head and Neck Cancers.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: immune checkpoint inhibitors, immunomodulatory pathways, tumor microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.