The field of autoimmune diseases, including rheumatoid arthritis, lupus, and scleroderma, has recently seen significant advancements in understanding the role of cell death in disease pathogenesis. Autoimmune diseases are characterized by the immune system's aberrant attack on the body's own tissues, and recent research has highlighted cell death as a crucial factor in triggering these responses. Cell death can occur through apoptosis or necrosis, both of which may inadvertently initiate autoimmune responses by releasing cellular components and molecules that the immune system mistakenly identifies as foreign. This process can lead to the release of autoantigens, which are targeted by the immune system, exacerbating inflammation and tissue damage. Despite these insights, the complex interplay between cell death and autoimmune diseases remains a focal point of research, with ongoing studies aiming to unravel these interactions and develop new therapeutic strategies. Recent strides have illuminated critical facets of this challenge, including the mechanisms of cell death, the release of autoantigens, and the inflammatory signaling pathways involved. However, a comprehensive understanding of these processes and their implications for autoimmune diseases is still lacking, necessitating further investigation.

This research topic aims to explore the intricate interplay between autoimmune diseases and cell death, with a focus on advancing our understanding of the underlying mechanisms, novel insights, and potential therapeutic avenues. The primary objectives include investigating the different modes of cell death and their relevance to autoimmune disorders, elucidating the release of autoantigens during cell death, and exploring therapeutic strategies aimed at modulating cell death processes to mitigate autoimmune reactions. By addressing these objectives, the research seeks to answer critical questions about the factors driving autoimmunity and to develop innovative therapeutic strategies tailored to individual autoimmune conditions.

To gather further insights into the mechanisms and interplay of cell death in autoimmune diseases, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms of Cell Death: Investigations into different modes of cell death and their relevance to autoimmune disorders.
- Autoantigen Release: Studies elucidating the release of autoantigens during cell death and their role in triggering autoimmune responses.
- Immunomodulation: Research on therapeutic strategies aimed at modulating cell death processes to mitigate autoimmune reactions.
- Inflammatory Signaling: Exploring the signaling pathways and molecules involved in cell death and their contribution to autoimmune disease-related inflammation.

Submissions should contribute to advancing our knowledge in this critical field and may encompass experimental, clinical, or theoretical aspects.

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Frontiers in Immunology

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