About this Research Topic
Tigecycline (TIG), a third-generation tetracycline within the glycylcycline class, serves as a last-resort antibiotic for severe infections by multidrug-resistant bacteria. Predominantly, it treats infections from carbapenem and colistin-resistant strains, emphasizing its crucial role in critical healthcare scenarios. Unlike its predecessors, tigecycline is exclusively used in human medicine, enhancing its importance. Currently, the improper use of earlier tetracyclines and the growing dependence on tigecycline have led to the emergence of resistant bacterial strains. These developments stress the urgent need to understand tigecycline resistance mechanisms, presenting a major barrier to effective treatment.
This Research Topic aims to delve into the epidemiology, phenotypic, and genotypic characteristics of tigecycline-resistant organisms while identifying innovative diagnostic and control strategies. The focus is on unraveling the mechanisms behind resistance and exploring potential risk factors. The goal is to enhance detection, treatment, and prevention methods to curb the spread of these pathogens, as well as preserve the effectiveness of tetracyclines.
To gather further insights into the epidemiology and traits of TIG resistance, we welcome articles addressing, but not limited to, the following themes:
-Advances in phenotypic and genotypic diagnostic techniques for TIG resistance
-Epidemiological patterns of TIG resistance within the One Health triad
-Impact of environmental and socioeconomic factors on the spread of TIG-resistant strains
-Development and evaluation of new tetracycline derivatives or alternative therapeutic strategies
-Policy and preventive measures to limit the misuse of tetracycline and manage resistance effectively
The scope of this research collection spans current knowledge gaps, technological advancements, and collaborative efforts across disciplines to confront one of the most pressing public health concerns of our time.
This Research Topic aims to delve into the epidemiology, phenotypic, and genotypic characteristics of tigecycline-resistant organisms while identifying innovative diagnostic and control strategies. The focus is on unraveling the mechanisms behind resistance and exploring potential risk factors. The goal is to enhance detection, treatment, and prevention methods to curb the spread of these pathogens, as well as preserve the effectiveness of tetracyclines.
To gather further insights into the epidemiology and traits of TIG resistance, we welcome articles addressing, but not limited to, the following themes:
-Advances in phenotypic and genotypic diagnostic techniques for TIG resistance
-Epidemiological patterns of TIG resistance within the One Health triad
-Impact of environmental and socioeconomic factors on the spread of TIG-resistant strains
-Development and evaluation of new tetracycline derivatives or alternative therapeutic strategies
-Policy and preventive measures to limit the misuse of tetracycline and manage resistance effectively
The scope of this research collection spans current knowledge gaps, technological advancements, and collaborative efforts across disciplines to confront one of the most pressing public health concerns of our time.
Keywords: threat, health, mobile tigecycline resistance, overuse, antimicrobial resistance, tigecycline clinical effectiveness, TIG, tetracycline
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
