About this Research Topic
Despite intense research efforts, the mechanisms that govern the differentiation, expansion, and function of tumor-associated myeloid cells remain incompletely understood. Novel approaches that reprogram myeloid cells to facilitate or induce productive antitumor immunity are highly sought after.
In this Research Topic, we invite original research articles and mini-reviews that delve into the causal mechanisms regulating the biology of tumor-associated myeloid cells. The scope includes, but is not limited to:
1. Studies on cellular processes governing the plasticity and physiology of tumor-associated myeloid cells, encompassing migration, metabolic regulation, and cell cycle control.
2. Exploration of molecular events, signaling cascades, and transcriptional networks that promote the differentiation and expansion of tumor-associated myeloid cells.
3. Phenotypic and functional characterizations of cancer-associated myeloid cells in both murine models and human cancer specimens.
4. Novel approaches aimed at reducing their abundance or reprogramming these cells to stimulate innate and adaptive antitumor immune responses.
5. Evaluation of the biomarker value and mechanisms associated with drug resistance mediated by tumor-associated myeloid cells.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Tumor-associated myeloid cells, DCs, macrophages, immature
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.