Blood-borne viral infections such as hepatitis B (HBV), hepatitis C (HCV), hepatitis Delta (HDV), and human immunodeficiency virus (HIV) pose major health challenges in low and middle-income countries (LMICs), contributing significantly to morbidity and mortality. These viruses are notable for their dynamic evolutionary processes and complex transmission patterns, which are crucial for developing effective medical interventions. Understanding these factors is critical as LMICs often lack the resources needed for widespread diagnostic and treatment programs. The genomic adaptations of these viruses, influenced by diverse human populations and varying environments, offer a reservoir of information that can drive innovations in disease management and intervention strategies.

This Research Topic seeks to collate and disseminate cutting-edge research that addresses the burden, diagnosis, diversity, treatment, and prevention of blood-borne viral infections in LMICs. The aim is to expand the existing scientific literature by incorporating new studies that leverage molecular epidemiology, viral genomics, and innovative healthcare solutions. By integrating these multifaceted approaches, the collection aims to enhance understanding of the viral characteristics and social dynamics that influence the spread of these diseases.

We invite contributions that cover a broad spectrum of research areas including:
- Molecular surveillance of blood-borne viruses in low-resource settings and how these data can inform public health interventions.
- Development and application of genomic tools for diagnostics, as well as antiviral drug and vaccine discovery, tailored to the needs and constraints of LMICs.
- Innovative prevention and control strategies that address both the biological and socio-economic determinants of disease spread.
- Analysis of antiviral resistance and its implications for treatment regimes.
- Studies on the evolutionary and spatio-temporal dynamics of these viruses within and across different populations and regions.
- Investigations into how behavioral adaptations and policy decisions affect the management of these infections.

Submissions are encouraged in various formats, including original research, clinical trial reports, systematic reviews, and perspectives that offer insights into both the scientific and policy-making aspects of blood-borne viral infections control. This Research Topic aims to foster a better understanding of the landscape of viral infections in LMICs and encourage the development of effective, sustainable strategies to mitigate their impact.

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Frontiers in Virology

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