About this Research Topic
Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with unclear etiology. IBD has emerged as major global public health concern. The incidence rate is notably high in developed regions like Europe and America, while developing regions like Asia and Africa are also witnessing a rise in incidence rate. Many researchers have focused on investigation of complementary and alternative drugs (CAM). The use of natural bioactive compounds to mitigate symptoms of inflammatory diseases is one of the emerging strategies.
Carotenoids are natural terpenoid pigments with strong antioxidant and anti-inflammatory abilities by directly quenching reactive oxygen species (ROS) and clearing free radicals, as well as indirectly regulating anti-inflammatory signaling pathways. Carotenoids have considerable application potential in alleviating IBD and other inflammatory diseases. However, in the molecular structure of carotenoids, due to the presence of conjugated double bonds, the strong hydrophobicity and limited stability in the gastrointestinal tract resulting in low bioavailability. Direct oral administration of carotenoids may also lead to low inflammation site specificity.
It has become an effective, efficient and reliable approach to construct nutrient delivery systems for carotenoids based on biopolymer nanoparticles, emulsion, solid lipids, liposomes and microcapsules. It is beneficial to improve the stability, solubility, permeability, and bioavailability of carotenoids, achieving targeted controlled release of carotenoids such as lutein, astaxanthin, and lycopene, etc., thereby promoting the development of antioxidant and anti-inflammatory functional foods and nutritional supplements. The goal of the research topic is to investigate the construction of novel delivery systems loaded with carotenoids, the intestinal release performance and transmembrane transport of carotenoids, and their action mechanisms of alleviating various inflammatory diseases. The aim is to provide valuable insights and guidance for exploring new nutritional delivery systems and their applications in inflammatory diseases.
This research topic welcome submissions of original research , Review article, including but not limited to the following area:
• Preparation and characterization of novel nutraceutical delivery systems for carotenoids
• The influence of nano delivery systems on the antioxidant and anti-inflammatory activities of carotenoids
• Cellular activities of carotenoids in different delivery systems
• Digestion, absorption, bioavailability, and metabolic patterns of nutraceutical delivery systems for carotenoids
• The targeted release effect of nutraceutical delivery system for carotenoids in the intestine
• Interacting with other functional components to prevent/alleviate inflammatory diseases or other biological activities;
• The application of novel nutraceutical delivery systems for carotenoids in functional foods or nutritional supplements
Carotenoids are natural terpenoid pigments with strong antioxidant and anti-inflammatory abilities by directly quenching reactive oxygen species (ROS) and clearing free radicals, as well as indirectly regulating anti-inflammatory signaling pathways. Carotenoids have considerable application potential in alleviating IBD and other inflammatory diseases. However, in the molecular structure of carotenoids, due to the presence of conjugated double bonds, the strong hydrophobicity and limited stability in the gastrointestinal tract resulting in low bioavailability. Direct oral administration of carotenoids may also lead to low inflammation site specificity.
It has become an effective, efficient and reliable approach to construct nutrient delivery systems for carotenoids based on biopolymer nanoparticles, emulsion, solid lipids, liposomes and microcapsules. It is beneficial to improve the stability, solubility, permeability, and bioavailability of carotenoids, achieving targeted controlled release of carotenoids such as lutein, astaxanthin, and lycopene, etc., thereby promoting the development of antioxidant and anti-inflammatory functional foods and nutritional supplements. The goal of the research topic is to investigate the construction of novel delivery systems loaded with carotenoids, the intestinal release performance and transmembrane transport of carotenoids, and their action mechanisms of alleviating various inflammatory diseases. The aim is to provide valuable insights and guidance for exploring new nutritional delivery systems and their applications in inflammatory diseases.
This research topic welcome submissions of original research , Review article, including but not limited to the following area:
• Preparation and characterization of novel nutraceutical delivery systems for carotenoids
• The influence of nano delivery systems on the antioxidant and anti-inflammatory activities of carotenoids
• Cellular activities of carotenoids in different delivery systems
• Digestion, absorption, bioavailability, and metabolic patterns of nutraceutical delivery systems for carotenoids
• The targeted release effect of nutraceutical delivery system for carotenoids in the intestine
• Interacting with other functional components to prevent/alleviate inflammatory diseases or other biological activities;
• The application of novel nutraceutical delivery systems for carotenoids in functional foods or nutritional supplements
Keywords: Nutrient Delivery System, Carotenoids, Bioavailability, Antioxidant Activity, Anti-inflammatory Activity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
