About this Research Topic
Hyperuricemia (HUA) is a metabolic disease caused by purine metabolism disorder, which is an important hub for many chronic diseases such as gout, diabetes, and hypertension. Therefore, how to prevent and treat HUA has become the focus of global attention. HUA is a disease closely related to diet, and diet therapy has a certain auxiliary effect on improving the quality of life of patients with HUA. Plant metabolites have the characteristics of multi-link, multi-level, and multi-target, and their development has become a new idea for the development of urate-reducing drugs, reducing toxicity and increasing efficacy, and auxiliary treatment of high uric acid food. In recent years, more and more studies have been devoted to mining natural substances with uric acid-reducing activity from plants, combining secondary genomics, metabolomics, and proteomics of plant metabolites to explore the intervention and influence of plant metabolites on purine metabolism and uric acid synthesis in vivo. Studies have shown that plant metabolites, such as flavonoids, saponins, polysaccharides, and polyphenols, prevent or treat HUA and its complications by regulating uric acid metabolism through inhibition of the activity of key enzymes for uric acid synthesis and regulating uric acid transporters such as OAT1, ABCG2, GLUT9, and URAT1.
This Research Topic aims to summarize the status of plant metabolites and hyperuricemia model construction. And to analyze the production and metabolic pathways of plant metabolites regulating purine and uric acid in terms of inhibiting uric acid synthesis, promoting uric acid excretion, protecting kidney and intestinal function, improving intestinal flora disorder, and reducing inflammation. Thus, providing a theoretical basis for the research and development of natural uric acid-lowering products that regulate purine metabolism in vivo.
Bullet points are as below:
· Purine metabolism and uric acid production pathway in the human body.
· Current status of the extraction and analysis of plant metabolites and hyperuricemia model construction.
· From the aspects of inhibiting uric acid synthesis, promoting uric acid excretion, protecting kidney and intestinal function, improving intestinal flora disorder, and reducing inflammation, the pathway of uric acid metabolism regulated by plant metabolites was analyzed.
· Prospect the future development trend of plant metabolites in the field of uric acid.
This Research Topic aims to summarize the status of plant metabolites and hyperuricemia model construction. And to analyze the production and metabolic pathways of plant metabolites regulating purine and uric acid in terms of inhibiting uric acid synthesis, promoting uric acid excretion, protecting kidney and intestinal function, improving intestinal flora disorder, and reducing inflammation. Thus, providing a theoretical basis for the research and development of natural uric acid-lowering products that regulate purine metabolism in vivo.
Bullet points are as below:
· Purine metabolism and uric acid production pathway in the human body.
· Current status of the extraction and analysis of plant metabolites and hyperuricemia model construction.
· From the aspects of inhibiting uric acid synthesis, promoting uric acid excretion, protecting kidney and intestinal function, improving intestinal flora disorder, and reducing inflammation, the pathway of uric acid metabolism regulated by plant metabolites was analyzed.
· Prospect the future development trend of plant metabolites in the field of uric acid.
Keywords: hyperuricemia, uric acid, natural product, metabolism, mechanism
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