Recently, the incidence of zoonoses has shown a global upward trend. There are more than 60 emerging infectious diseases and re-emerging infectious diseases worldwide, more than half of which are zoonotic. Drugs play a pivotal role in both the treatment and prevention of zoonoses. Through the research and analysis of the mechanisms and targets of viral infection, effective and safe drugs can be designed. For instance, bioinformatics has been employed to analyze genomes, proteomes, and metabolomes, enabling the identification of disease and drug targets through high-throughput technology. This approach has led to the discovery of numerous natural compounds with anti-zoonotic properties.

By studying the relationship between medications and disease targets, we can uncover the mechanisms of action underlying these treatments. This knowledge provides valuable guidance for the precise design and application of drugs. Additionally, delving deeper into the mechanisms of action of screened drugs on diseases can shed light on combination drug therapies and help elucidate the therapeutic mechanisms of active ingredients at the biomolecular level.

In conclusion, continuous development in understanding the pathogenesis of zoonoses and the mechanisms of action of drugs is essential. This approach allows us to gain a comprehensive understanding of the intricate interactions between medications, diseases, and biological systems. By examining human organs, diseases, metabolic pathways, and target proteins from multiple perspectives, we can make significant progress in combating zoonotic diseases.

This Research Topic focuses on the mechanisms of zoonoses and therapeutic drugs. Zoonoses encompass viral diseases, bacterial diseases, and other zoonotic diseases. The drugs under investigation include natural molecules, synthetic drugs, antibodies, and other types of medications. The primary objective of this Research Topic is to discover more effective drugs for zoonoses and study the interaction mechanisms between therapeutic drugs and zoonotic diseases. By understanding these mechanisms, we can develop novel treatment strategies and improve the efficacy of existing drugs. Additionally, this research will contribute to our knowledge of zoonoses and help develop preventive measures and control strategies for these diseases.

We welcome submissions addressing topics including but not limited to the following:
- Drug-target interaction: Drugs interact with specific molecular targets in the body, such as proteins, enzymes, receptors, or nucleic acids. These interactions determine the drug's mechanism of action and its ability to modulate biological processes.
- Disease-pathway interaction: Diseases involve alterations in biological pathways or processes. Drugs act by targeting specific pathways or processes dysregulated in the disease state.
- Drug-biomarker interaction: Biomarkers are measurable biological indicators that reflect the presence or progression of a disease. Drugs can modulate the expression or activity of specific biomarkers, providing insights into the drug's therapeutic efficacy or potential side effects.
- Systemic and off-target effects: Drugs can affect not only the intended target but also other molecules or systems in the body. These systemic and off-target effects can lead to both therapeutic and adverse effects.
- Host-pathogen interactions: In the case of zoonotic diseases, the interaction between the host and the pathogen plays a critical role. Drugs can target specific interactions between the host and the pathogen, disrupting the infection process, modulating the host immune response, or inhibiting the pathogen's survival or replication.

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Frontiers in Cellular and Infection Microbiology

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