About this Research Topic
The field of gene therapy stands as a pioneering area of research, positioned at the intersection of molecular biology, medicine, and biotechnology. Its primary goal is to treat, cure, or prevent diseases by manipulating gene expression within cells through the introduction, modification, or suppression of genes. Early research in gene therapy concentrated on rectifying genetic disorders stemming from gene mutations. However, over time, the scope of gene therapy has broadened significantly, encompassing a diverse array of diseases. These range from monogenic disorders to intricate, multifactorial conditions like cancer and cardiovascular diseases. The evolution of sophisticated molecular techniques, coupled with an enhanced comprehension of the human genome, has substantially accelerated progress within this domain. Researchers employ a variety of delivery mechanisms to introduce therapeutic genes into target cells, with viral and non-viral vectors emerging as notable and prevalent methodologies.
The objective of this research topic is to tackle the persistent challenges and capitalize on advancements in the dynamic realm of gene therapy. Despite significant progress, hurdles such as vector safety, immune responses, and delivery efficiency remain prevalent. Our goal is to encourage research that delves into the molecular intricacies of gene therapy, fostering a deeper understanding of its underlying molecular mechanisms. Additionally, we aim to explore potential synergies resulting from the integration of gene therapy with diverse treatment modalities, including immunotherapy and conventional pharmaceutical interventions. Moreover, this research initiative promotes the exploration of pioneering therapeutic strategies. Contributors are encouraged to propel the field forward by devising innovative solutions aimed at enhancing the precision, safety, and efficacy of gene therapies.
This research topic aims to explore cutting-edge innovations in gene therapy and its applications across a wide spectrum of diseases, involving both viral and non-viral vectors. We invite contributions that delve into novel therapeutic strategies, pioneering vector designs, and advancements in gene delivery systems. Topics of interest include, but are not limited to, the treatment of chronic and acute diseases, as well as the integration of gene medicine approaches. We encourage research that investigates the intricate molecular mechanisms underlying gene therapy. We warmly welcome original research articles, reviews, and opinions that substantially contribute to the comprehension and advancement of gene therapy. Manuscripts should offer fresh insights, experimental evidence, and potential clinical implications. Submissions focusing on advancements in vector development, delivery technologies, and preclinical or clinical studies are particularly encouraged.
• Intricacies of Gene Therapy Mechanisms: Emphasis is on understanding gene expression manipulation's effects on disease prevention, treatment, or cure.
• Gene Therapy & Treatment Modalities Synergies: Emphasis on exploration of the integrative potential of gene therapy with treatment modalities like immunotherapy pharmaceutical interventions, particularly for multifactorial diseases.
• Breakthroughs in Vector & Delivery Systems: emphasis on innovative solutions for pioneering therapeutic strategies, focusing on vector safety, immune responses, and delivery efficiency to enhance gene therapies' precision, safety, and efficacy. Contributions demonstrating experimental evidence and potential clinical implications are highly valued.
The objective of this research topic is to tackle the persistent challenges and capitalize on advancements in the dynamic realm of gene therapy. Despite significant progress, hurdles such as vector safety, immune responses, and delivery efficiency remain prevalent. Our goal is to encourage research that delves into the molecular intricacies of gene therapy, fostering a deeper understanding of its underlying molecular mechanisms. Additionally, we aim to explore potential synergies resulting from the integration of gene therapy with diverse treatment modalities, including immunotherapy and conventional pharmaceutical interventions. Moreover, this research initiative promotes the exploration of pioneering therapeutic strategies. Contributors are encouraged to propel the field forward by devising innovative solutions aimed at enhancing the precision, safety, and efficacy of gene therapies.
This research topic aims to explore cutting-edge innovations in gene therapy and its applications across a wide spectrum of diseases, involving both viral and non-viral vectors. We invite contributions that delve into novel therapeutic strategies, pioneering vector designs, and advancements in gene delivery systems. Topics of interest include, but are not limited to, the treatment of chronic and acute diseases, as well as the integration of gene medicine approaches. We encourage research that investigates the intricate molecular mechanisms underlying gene therapy. We warmly welcome original research articles, reviews, and opinions that substantially contribute to the comprehension and advancement of gene therapy. Manuscripts should offer fresh insights, experimental evidence, and potential clinical implications. Submissions focusing on advancements in vector development, delivery technologies, and preclinical or clinical studies are particularly encouraged.
• Intricacies of Gene Therapy Mechanisms: Emphasis is on understanding gene expression manipulation's effects on disease prevention, treatment, or cure.
• Gene Therapy & Treatment Modalities Synergies: Emphasis on exploration of the integrative potential of gene therapy with treatment modalities like immunotherapy pharmaceutical interventions, particularly for multifactorial diseases.
• Breakthroughs in Vector & Delivery Systems: emphasis on innovative solutions for pioneering therapeutic strategies, focusing on vector safety, immune responses, and delivery efficiency to enhance gene therapies' precision, safety, and efficacy. Contributions demonstrating experimental evidence and potential clinical implications are highly valued.
Keywords: Gene therapy, targeted disease treatment, gene delivery systems, functional materials, translational research
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
