Infectious diseases continue to pose a significant threat to global health, driven by pathogenic microorganisms such as bacteria, viruses, parasites, and fungi. The complexity of treating these diseases is compounded by the need for precise drug delivery to maximize therapeutic efficacy while minimizing side effects.
The ADME (Absorption, Distribution, Metabolism, and Elimination) processes of anti-infective drugs are crucial in determining their effectiveness. Variability in absorption, tissue-specific distribution, biotransformation pathways, and elimination kinetics can significantly impact the efficiency of these drugs. Recent studies have highlighted the importance of understanding these processes to improve drug delivery and efficacy, particularly in diseases like Malaria, SARS-CoV-2, and Tuberculosis. However, there remains a gap in comprehensive knowledge regarding the ADME characteristics of anti-infective drugs, necessitating further research to address these challenges and enhance treatment outcomes.

This research topic aims to deepen our understanding of the ADME processes of drugs used to treat infectious diseases. By investigating the pharmacokinetics, distribution, metabolism, and elimination of anti-infective drugs, we seek to answer critical questions about their absorption variability, tissue-specific distribution, and the impact of genetic polymorphisms on drug metabolism. The goal is to develop novel methodologies and provide substantial insights that can lead to more effective and targeted treatments for infectious diseases.

To gather further insights into the ADME processes of anti-infective drugs, we welcome articles addressing, but not limited to, the following themes:

- Pharmacokinetics of anti-infective drugs, including the impact of physicochemical properties on absorption and bioavailability.

- Tissue-specific distribution patterns and drug penetration in infected tissues, including the ability to cross the blood-brain barrier.

- Biotransformation pathways and the role of drug-metabolizing enzymes, including the formation of active metabolites.

- Elimination kinetics, including renal and hepatic clearance, and factors influencing drug half-life.

Submissions for the following article types are welcome: Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology, and Code

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Frontiers in Pharmacology

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