About this Research Topic
By enhancing our understanding of the ADME processes of anti-infective drugs used to treat for example infectious diseases, like Malaria, SARS-CoV-2, or Tuberculosis, can improve the precise delivery of these drugs to target sites, thereby maximizing therapeutic efficacy and minimizing potential side effects.
The absorption variability, tissue-specific distribution, biotransformation pathways, and elimination kinetics affect the efficiency of anti-infective drugs.
Thus, we seek contributions that explore novel methodologies, provide substantial insights, and address pressing challenges in this dynamic field.
Manuscripts will focus on (but are not limited to) the following topics:
1. Pharmacokinetics of Anti-Infective Drugs: This research topic will investigate the ADME characteristics of antibiotics, antivirals, antiparasitics, and antifungals, assess the impact of physicochemical properties on drug absorption and bioavailability, and examine the variability in drug absorption due to factors such as age, disease state, and concomitant medications.
2. Distribution of Anti-Infective Drugs: we will welcome manuscripts assessing the tissue-specific distribution patterns and drug penetration in infected tissues, the impact of protein binding on drug distribution and efficacy, and the ability of drugs to penetrate the blood-brain barrier to effectively treat central nervous system infections.
3. Metabolism of Anti-Infective Drugs: In addition, the collection will explore biotransformation pathways and the role of drug-metabolizing enzymes, investigate the formation of active metabolites their pharmacokinetics, and their contribution to therapeutic effects, as well as understand the role of genetic polymorphisms and their impact on drug metabolism and efficacy
4. Elimination of Anti-Infective Drugs: The collection will consider renal clearance and the need for dose adjustment in patients with renal impairment, the implications of hepatic clearance for drug-drug interactions, and explore the elimination kinetics and factors influencing drug half-life
Submissions for the following article types are welcome: Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology, and Code
Keywords: ADME of Drugs, Infectious Diseases, Pharmacokinetics, Distribution, Elimination, Anti-Infective Drugs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.