Hypertension is a chronic clinical condition characterized by cardiovascular physiological impairment. It occurs when blood pressure is persistently high, leading to compromising blood vessels and increasing the risk of severe conditions such as heart disease, stroke, and renal insufficiency. The cardiorenal syndrome is a clinical condition in which there is a complex interaction between cardiac and
renal functions, resulting in a bidirectional relationship, where the malfunction of one organ can lead to problems in the other. The
relationship between the heart and kidneys is complex, and the cardiorenal syndrome is an area of active research, as understanding and treating this interaction may be crucial to improving clinical outcomes in patients with cardiovascular and kidney diseases.

Currently, there is no effective pharmacological treatment for cardiorenal syndrome. The therapeutic maneuvers used consist of treating cardiac and renal pathological conditions separately. Hypertension is a chronic disease that can lead to various circulatory, renal, and cardiac pathologies in a context worsened by aging. Understanding the molecular mechanisms associated with the genesis of hypertension and cardiorenal syndrome, as well as the search for new and effective pharmacological therapies, arouses a central interest in this Research Topic. Studying these molecular mechanisms in this context can include innovative approaches to oxidative stress, inflammation, epigenetics, and traditional approaches related to the renin-angiotensin-aldosterone system, adrenergic signaling, fluid management, and ions such as Na + and Ca 2+ . Using in vitro models, experimental animals, or clinical studies with humans can be crucial in understanding the development of these pathologies. Discoveries focusing on personalized treatment and precision medicine attract particular attention to studying hypertension and cardiorenal syndrome as effective strategies for population health, focusing mainly on improving the quality of life-related to aging.

New submissions addressing recent advances in basic and clinical research on hypertension and cardiorenal syndrome and underlying chronic cardiac and renal pathologies are welcome. These papers can be original contributions or reviews. Papers that address the relationship between these diseases and aging have priority. Areas to be covered in this Research Topic may include, but are not limited to:

• Hypertension at different ages
• Sex differences in hypertension
• Hypertension and its relationship with nutritional status
• Vascular changes in hypertension
• Pathophysiology of hypertension
• Involvement of the intestinal microbiome in hypertension
• Hypertension and the immune system
• Oxidative stress and hypertension
• Epigenetic mechanisms related to hypertension
• Changes related to the renin-angiotensin-aldosterone system in hypertension
• Hypertension and adrenergic signaling
• New therapeutic approaches in the treatment of hypertension
• Molecular mechanisms related to cardiorenal syndrome
• Acute and chronic kidney disease
• Acute and chronic cardiac pathologies

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Frontiers in Aging

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