About this Research Topic
The initial period of life, known as the first one thousand days is critical for the organism in development and any insult or harm, in this period, can lead to crucial and permanent changes in epigenetic and/or molecular levels that may predispose to metabolic disorders as like as obesity, diabetes, reproductive dysfunction, impaired of growth or cognitive changes throughout life. At present, the adolescence period is
understand also as critical period for development. The hormonal, nutritional, stressors or same environmental pollutants are factors of potential action disruptive in these periods of life and may be responsible for metabolic future complications with damage to healthy
life.
The research topic seeks to contribute to studies with a focus on critical periods of life and different external influences in these phases that compromise healthy development. The periods such as preconception, gestation, lactation, and adolescence can determine the functionality of our organism at long-term increasing the predisposition to endocrine-metabolic disorders, phenomena called DOHaD hypothesis (Developmental Origins of Health and Disease). The mechanisms by which in this period external factors affect the central regulation of energy balance and metabolism could be distinctly dependent on insult type, intensity, gender, and specific period where insult occurs.
Nowadays, there is a consensus that the health-disease status in adulthood can be determined by potential insults that occur in early periods of life (i.e. preconception, gestation, lactation and adolescence) and understanding these mechanisms becomes an
urgent issue.
In this topic will accepted studies of various type, such as hypothesis & theory, methods, mini review, original research and systematic review on the following interventions models:
- Denutrition and/or overnutrition conditions
- Interventions with drugs and pharmaceuticals
- Critical periods essential for health development
- Exposure to environmental disruptors chemicals
- Disruption in hormonal profile
- Stressors events and its impacts on development
understand also as critical period for development. The hormonal, nutritional, stressors or same environmental pollutants are factors of potential action disruptive in these periods of life and may be responsible for metabolic future complications with damage to healthy
life.
The research topic seeks to contribute to studies with a focus on critical periods of life and different external influences in these phases that compromise healthy development. The periods such as preconception, gestation, lactation, and adolescence can determine the functionality of our organism at long-term increasing the predisposition to endocrine-metabolic disorders, phenomena called DOHaD hypothesis (Developmental Origins of Health and Disease). The mechanisms by which in this period external factors affect the central regulation of energy balance and metabolism could be distinctly dependent on insult type, intensity, gender, and specific period where insult occurs.
Nowadays, there is a consensus that the health-disease status in adulthood can be determined by potential insults that occur in early periods of life (i.e. preconception, gestation, lactation and adolescence) and understanding these mechanisms becomes an
urgent issue.
In this topic will accepted studies of various type, such as hypothesis & theory, methods, mini review, original research and systematic review on the following interventions models:
- Denutrition and/or overnutrition conditions
- Interventions with drugs and pharmaceuticals
- Critical periods essential for health development
- Exposure to environmental disruptors chemicals
- Disruption in hormonal profile
- Stressors events and its impacts on development
Keywords: metabolism, development, outcomes, nutrition, endocrine disorders
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
