About this Research Topic
The main goal of this collection of articles is to present new findings in state-of-the-art imaging analysis, genetic studies, RNA sequencing (bulk, single-cell, and spatial transcriptomics), immunohistochemical studies of atherosclerotic plaques, biomechanical and hemodynamic studies, through to identify prognostic tools and mechanisms based on which to develop, in the future, new therapeutic strategies to prevent cerebrovascular events and to improve peri-operative evolution.
We welcome any types of papers apart from Case Reports.
The scope of this research topic involves advancing our understanding of the disease process and developing innovative strategies for more targeted and personalized interventions. Here are several critical areas of focus:
Genomic Research: Further exploration of genetic factors associated with susceptibility to carotid atherosclerosis and its progression.
Biomarkers: Continued research into biomarkers that can reliably predict atherosclerotic plaques' presence, activity, and vulnerability. Early and accurate identification of high-risk plaques can guide timely interventions.
Molecular Imaging: Developing imaging techniques that allow for the visualization of molecular and cellular processes within atherosclerotic plaques.
Tissue Engineering: Exploring tissue engineering approaches to develop bioengineered vessels that can replace or support damaged portions of the carotid arteries.
Biomechanical analysis: Exploring the impact of the atherosclerotic plaque's composition on the arterial wall's biomechanical profile.
Keywords: strokes, carotid endarterectomy, plaque vulnerability, cerebral hypoxia, cerebral hyperperfusion, biomarker, endovascular treatment, histopathology, plaque rupture, re-stenosis, inflammation, extracellular matrix, risk factors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.