About this Research Topic
Natural products with biological activity are an important source of innovative drugs. Statistics show that over half of small molecule drugs come from natural products and their analogues. At the same time, the development of efficient synthesis methods and the evaluation of the functional activity of related active molecules, as necessary steps to obtain corresponding innovative drugs, have always been at the forefront of research for organic chemists and pharmaceutical chemists. In addition, the quality evaluation of natural products and their derivatives, including bioactive molecule, exogenous harmful substances and endogenous toxic components, will be guaranteed to ensure the safe and effective clinical treatment.
Recently, the research community has made significant progress in the design and synthesis of bioactive molecules, the discovery of new natural products, the total synthesis of natural products, and the development of synthesis methods based on bioactive scaffolds. Therefore, we hope to collect, summarize and showcase the latest progress in the synthesis strategies, bioactivity evaluation, and quality control of natural products and their derivatives through this album, and provide new methods and template molecules for the development of innovative drug molecules in the future.
Welcome to submit original research articles, mini comments, and viewpoints on this research topic, which may include but are not limited to:
(1) Separation, structural elucidation, and biological evaluation of natural products;
(2) Synthesis and biological evaluation of bioactive molecules based on natural products;
(3) Efficient synthesis for key skeletons of bioactive natural products;
(4) Quality evaluation of natural products.
Please note:
If your MS is submitted to Frontiers in Pharmacology or involves plant or fungal extracts, please check your MS using the Four Pillars and the ConPhyMP tool (see https://ga-online.org/best-practice/; cf. ConPhyMP statement Front. Pharmacol. 13:953205. In your submission you need to include a PDF with the filled in datasets based on Table 1 and one of the tables in section 2 . Please note the traditional context including the primary background and modern uses with supporting references must be included in the manuscript's introduction.
Recently, the research community has made significant progress in the design and synthesis of bioactive molecules, the discovery of new natural products, the total synthesis of natural products, and the development of synthesis methods based on bioactive scaffolds. Therefore, we hope to collect, summarize and showcase the latest progress in the synthesis strategies, bioactivity evaluation, and quality control of natural products and their derivatives through this album, and provide new methods and template molecules for the development of innovative drug molecules in the future.
Welcome to submit original research articles, mini comments, and viewpoints on this research topic, which may include but are not limited to:
(1) Separation, structural elucidation, and biological evaluation of natural products;
(2) Synthesis and biological evaluation of bioactive molecules based on natural products;
(3) Efficient synthesis for key skeletons of bioactive natural products;
(4) Quality evaluation of natural products.
Please note:
If your MS is submitted to Frontiers in Pharmacology or involves plant or fungal extracts, please check your MS using the Four Pillars and the ConPhyMP tool (see https://ga-online.org/best-practice/; cf. ConPhyMP statement Front. Pharmacol. 13:953205. In your submission you need to include a PDF with the filled in datasets based on Table 1 and one of the tables in section 2 . Please note the traditional context including the primary background and modern uses with supporting references must be included in the manuscript's introduction.
Keywords: Natural products, Bioactive molecules, Bioactivity evaluation, Chemical synthesis, Quality control
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
