About this Research Topic
Viruses are significant contributors to global diarrhea cases in humans and animals. Prior to the availability of effective vaccines, rotavirus was responsible for 30% to 70% of hospitalizations in children with acute gastroenteritis. Concurrently, norovirus emerged as the primary cause of community-acquired diarrhea, resulting in numerous outbreaks and foodborne illnesses. Rotavirus predominantly affects children under five, whereas norovirus is more prevalent in adults. Additionally, the porcine epidemic diarrhea virus (PEDV) has led to a global outbreak of porcine epidemic diarrhea. Currently, there are no approved drugs specifically targeting these viral infections. We suggest that a deeper understanding of virus-host interactions could give the way for innovative antiviral strategies.
The primary goal of this research topic is to unravel the complex interactions between diarrheic viruses and their host cells. Understanding these interactions is crucial as viruses exploit cellular mechanisms for replication, manipulate host cell machinery, and evade immune defenses. At the molecular level, these involve physical and functional interactions between viral and host proteins. By constructing comprehensive virus-host interactomes, researchers can identify key cellular proteins essential for the viral life cycle. These proteins present potential targets for novel antiviral therapies that aim to disrupt viral replication by targeting host factors. Such host-oriented therapeutic strategies are anticipated to overcome current limitations in antiviral treatments and combat increasing instances of drug resistance. Ultimately, this research aims to enhance our understanding of viral pathogenesis and contribute to strategies for preventing and alleviating diarrhea-related diseases in both humans and animals.
This research topic specifically focuses on the study of virus-host interactions related to diarrhea in both humans and animals. Areas of interest include, but are not limited to:
-Studies on rotavirus, norovirus, porcine epidemic diarrhea virus, porcine transmissible gastroenteritis virus, bovine diarrhea virus, and other viruses associated with diarrheal diseases.
-Identification and analysis of antiviral and proviral host factors.
-Investigations into the mechanisms by which host factors influence viral replication and pathogenesis.
The primary goal of this research topic is to unravel the complex interactions between diarrheic viruses and their host cells. Understanding these interactions is crucial as viruses exploit cellular mechanisms for replication, manipulate host cell machinery, and evade immune defenses. At the molecular level, these involve physical and functional interactions between viral and host proteins. By constructing comprehensive virus-host interactomes, researchers can identify key cellular proteins essential for the viral life cycle. These proteins present potential targets for novel antiviral therapies that aim to disrupt viral replication by targeting host factors. Such host-oriented therapeutic strategies are anticipated to overcome current limitations in antiviral treatments and combat increasing instances of drug resistance. Ultimately, this research aims to enhance our understanding of viral pathogenesis and contribute to strategies for preventing and alleviating diarrhea-related diseases in both humans and animals.
This research topic specifically focuses on the study of virus-host interactions related to diarrhea in both humans and animals. Areas of interest include, but are not limited to:
-Studies on rotavirus, norovirus, porcine epidemic diarrhea virus, porcine transmissible gastroenteritis virus, bovine diarrhea virus, and other viruses associated with diarrheal diseases.
-Identification and analysis of antiviral and proviral host factors.
-Investigations into the mechanisms by which host factors influence viral replication and pathogenesis.
Keywords: rotavirus, norovirus, Porcine epidemic diarrhea virus, virus-host interaction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
