In recent years, extracellular vesicles (EVs) have emerged as pivotal mediators in intercellular communication. These naturally occurring vesicles, including exosomes and microvesicles, carry diverse biomolecules, such as proteins, nucleic acids, and lipids. EVs play a crucial role in various physiological and pathological processes, making them promising candidates for innovative disease therapies. The understanding of EVs' unique cargo and functions has paved the way for groundbreaking advancements in biomedical research. This Research Topic aims to delve into the diverse origins of EVs and explore their transformative impact on disease therapies. By harnessing the potential of EVs from different sources, researchers can unlock novel avenues for personalized, efficient, and targeted treatments. Join us in this exploration of EVs' origins and their significant role in shaping the future of modern medicine.

The primary goal of this Research Topic is to unravel the potential of EVs from diverse sources in revolutionizing disease management and treatment strategies. By focusing on EVs' unique cargo and functions derived from various origins, we aim to investigate their role in targeted drug delivery, diagnostic biomarkers, and innovative therapies. We strive to showcase cutting-edge research that explores the applications of EVs in different disease contexts, including cancer, neurodegenerative disorders, cardiovascular diseases, and autoimmune conditions. Moreover, we aim to emphasize the significance of understanding source-specific cargo for tailored treatments, highlighting regenerative medicine, RNA therapeutics, and personalized medicine strategies. Through this initiative, we seek to foster collaboration and knowledge exchange among scientists, clinicians, and researchers. By unraveling the distinctive properties of EVs and their functions, we aim to provide a comprehensive overview of the current state of EV-based therapies.

This Research Topic seeks contributions exploring the diverse applications of extracellular vesicles (EVs) from multiple sources in disease intervention. We encourage submissions that delve into EVs' roles but not limited to the following themes:
• EVs as natural drug delivery vehicles, emphasizing targeted therapy, minimized side effects, and enhanced treatment precision.
• Specific themes of interest include innovative therapies in cancer, neurodegenerative disorders, cardiovascular diseases, and autoimmune conditions, with a focus on gene-based treatments and immunomodulation techniques.
• The diagnostic utility of EVs as biomarkers for early disease diagnosis, progression monitoring, and therapeutic response assessment.
• The advancements in isolating, characterizing, and engineering EVs from various sources, including but not limited to plants, transgenic cell lines, and emerging stem cell technologies.

We welcome original research, reviews, and perspectives shedding light on the distinctive properties of EVs derived from diverse sources. The aim is to unravel novel avenues for disease intervention and therapy development. Manuscripts promoting collaboration and knowledge exchange are highly valued.

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Frontiers in Pharmacology

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