Anxiety and depression disorders are pervasive mental health issues that affect millions globally, transcending age and demographic boundaries. These disorders are often comorbid, meaning they frequently occur together, exacerbating their impact on individuals' emotional and functional capacities. Chronic stress is a significant factor that contributes to the onset and progression of these disorders, leading to metabolic disturbances, gut dysbiosis, and immune dysfunctions. Despite the prevalence of anxiety and depression, the underlying mechanisms, particularly those involving brain maladaptive plasticity, remain inadequately understood. Glial cells, which make up approximately 50% of the brain's cellular mass, play a crucial role in brain function and development. First identified in the 19th century, these cells are known for their diverse morphological and functional phenotypes. They are involved in guiding developmental processes, modulating neurotransmission, and maintaining neural plasticity. However, the specific contributions of glial cells to the pathogenesis of anxiety and depression are not fully elucidated, highlighting a significant gap in current research.

This research topic aims to explore the role of glial cells in the etiology and pathogenesis of anxiety and depression disorders. By focusing on these neural elements, the research seeks to uncover the principles and mechanisms by which glial cells influence the onset, progression, and consolidation of these mental health conditions. The objective is to address specific questions regarding the molecular and cellular pathways involved and to test hypotheses related to glial cell deregulation and its impact on brain function in the context of anxiety and depression.

To gather further insights into the role of glial cells in anxiety and depression, we welcome articles addressing, but not limited to, the following themes:
- The molecular and functional diversity of glial cells in the brain.
- The impact of chronic stress on glial cell function and its relation to anxiety and depression.
- Mechanisms of glial cell involvement in brain maladaptive plasticity.
- The role of glial cells in modulating neurotransmission and neuronal activity.
- Glial cell contributions to immune responses and blood-brain barrier properties in mental health disorders.
- Innovative therapeutic approaches targeting glial cells for anxiety and depression treatment.

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Frontiers in Cellular Neuroscience

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