About this Research Topic
The intricate relationship between diet, metabolic disorders, and cancer progression has attracted increasing attention. Excessive calorie intake triggers the production of reactive oxygen species (ROS), resulting in oxidative stress, which is a significant factor in the progression of these conditions. In obesity, this manifests as elevated inflammation levels due to calorie overload, while in type 2 diabetes(T2D), chronic hyperglycemia and lipidemia intensify oxidative stress and impair insulin secretion and insulin sensitivity of its target organs.
In addition, the heightened oxidative environment can drive DNA damage, which might contribute to cancer development and metastasis. Conversely, calorie restriction has been shown to attenuate oxidative stress, suggesting its potential in modulating the risk and progression of the above conditions. However, how specific dietary patterns or components exacerbate or mitigate oxidative stress at the molecular level, either systemically or in specific organs, is not yet fully elucidated.
The aim of this research topic is to explore the biological pathways linking calorie consumption-related oxidative stress with the pathophysiology of obesity, T2D, and cancer, highlighting potential therapeutic targets and prevention strategies. We strive to deepen the understanding of the mechanisms linking calorie consumption, oxidative stress, and the pathogenesis of obesity, T2D, and cancer, by highlighting novel insights into how dietary patterns and nutrients contribute to oxidative stress and subsequent disease progression. Furthermore, this topic is intended to explore innovative strategies in managing or mitigating the effects of oxidative stress through dietary interventions, pharmacological agents, or lifestyle modifications, thereby contributing to more effective prevention and treatment protocols.
We welcome submissions including but not limited to the following article types: original research articles, reviews, clinical trials, and methods that shed light on the following specific themes:
Mechanistic insights into oxidative stress pathways in obesity and T2D:
● Molecular mechanisms underlying the effects of excess calorie consumption/calorie restriction on oxidative stress in organs (such as islets, adipose, muscle, intestine, et al.) that contribute to obesity and T2D.
● The molecular basis of specific dietary components in modulating oxidative stress levels in obesity and T2D and their role in the disease progression.
Interplay between oxidative stress and cancer progression:
● Impact of oxidative stress derived from hypercaloric diets or calorie-restricted diets on tumor initiation, growth, and metastasis.
● Impact of obesity and T2D on cancer progression through oxidative stress-related pathways.
Nutritional interventions and antioxidant strategies:
●Novel indicators for evaluating dietary patterns, supplements, and specific nutrients that reflect oxidative stress levels in animal models or patients with obesity, T2D, and cancer.
●Clinical trials assessing the efficacy of antioxidant therapies in reducing oxidative stress markers and improving clinical outcomes.
Technological advancements in oxidative stress measurement:
●Development and validation of novel biomarkers and assays for assessing oxidative stress levels in clinical and research settings.
●Utilization of advanced imaging and molecular techniques to visualize and quantify oxidative damage in obesity, T2D, and cancer tissues.
In addition, the heightened oxidative environment can drive DNA damage, which might contribute to cancer development and metastasis. Conversely, calorie restriction has been shown to attenuate oxidative stress, suggesting its potential in modulating the risk and progression of the above conditions. However, how specific dietary patterns or components exacerbate or mitigate oxidative stress at the molecular level, either systemically or in specific organs, is not yet fully elucidated.
The aim of this research topic is to explore the biological pathways linking calorie consumption-related oxidative stress with the pathophysiology of obesity, T2D, and cancer, highlighting potential therapeutic targets and prevention strategies. We strive to deepen the understanding of the mechanisms linking calorie consumption, oxidative stress, and the pathogenesis of obesity, T2D, and cancer, by highlighting novel insights into how dietary patterns and nutrients contribute to oxidative stress and subsequent disease progression. Furthermore, this topic is intended to explore innovative strategies in managing or mitigating the effects of oxidative stress through dietary interventions, pharmacological agents, or lifestyle modifications, thereby contributing to more effective prevention and treatment protocols.
We welcome submissions including but not limited to the following article types: original research articles, reviews, clinical trials, and methods that shed light on the following specific themes:
Mechanistic insights into oxidative stress pathways in obesity and T2D:
● Molecular mechanisms underlying the effects of excess calorie consumption/calorie restriction on oxidative stress in organs (such as islets, adipose, muscle, intestine, et al.) that contribute to obesity and T2D.
● The molecular basis of specific dietary components in modulating oxidative stress levels in obesity and T2D and their role in the disease progression.
Interplay between oxidative stress and cancer progression:
● Impact of oxidative stress derived from hypercaloric diets or calorie-restricted diets on tumor initiation, growth, and metastasis.
● Impact of obesity and T2D on cancer progression through oxidative stress-related pathways.
Nutritional interventions and antioxidant strategies:
●Novel indicators for evaluating dietary patterns, supplements, and specific nutrients that reflect oxidative stress levels in animal models or patients with obesity, T2D, and cancer.
●Clinical trials assessing the efficacy of antioxidant therapies in reducing oxidative stress markers and improving clinical outcomes.
Technological advancements in oxidative stress measurement:
●Development and validation of novel biomarkers and assays for assessing oxidative stress levels in clinical and research settings.
●Utilization of advanced imaging and molecular techniques to visualize and quantify oxidative damage in obesity, T2D, and cancer tissues.
Keywords: ROS, high calorie, calorie restriction, metabolic disease, cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
