About this Research Topic
Kidneys regulate several functions, including electrolyte, water, and acid–base balance. Kidneys are indispensable in ensuring the body's homeostasis. Specific cells of the kidneys secrete various bioactive factors, such as renin, angiotensin-converting enzyme (ACE), vitamin D, and erythropoietin. The biomolecules and hormones secreted by the kidney regulate several physiological processes, such as blood pressure, erythropoiesis, and bone mineral metabolism. Impairment of kidney function progresses to chronic kidney disease (CKD), and one of the critical pathophysiological features of CKD is hypoxia.
Further, the risk factors associated with CKD evoke inappropriately low oxygen tension within the kidney. Systemic and intrarenal hypoxia is closely associated with fibrosis, inflammation, and CKD-related comorbidities such as sarcopenia, anemia, and cerebrovascular and cardiovascular events. Kidneys sense and respond to hypoxia, which is prevalent in extreme physiological or pathological conditions. The effect of hypoxia signaling on kidney function and injury is extensively investigated at the cellular and molecular levels. Adaptive and maladaptive responses by various parts of the kidney in response to hypoxia were extensively studied. Hypoxia signaling in the kidney is also explored therapeutically.
This collection aims to provide researchers, clinicians, and biologists with a state-of-the-art compilation of the activation of cellular and molecular responses to hypoxia in various kidney regions. This collection will provide a comprehensive understanding of the events that trigger in response to hypoxia and progress to varying degrees of kidney injury and presented with impaired kidney function. The intricate association of hypoxia with renal injury and maladaptive responses within the kidney will be reviewed. This article collection aims to provide data from in vitro experiments, experimental animals, clinical settings, and environmental conditions. This collection seeks to present the current and upcoming diagnostic and therapeutic approaches to combat hypoxia-associated CKD complications.
In this Research Topic, "Hypoxia Signaling and Renal Complications," we welcome contributions from researchers and clinicians exploring various aspects of hypoxia signaling in renal health and injury. We invite authors to submit original research articles, reviews, and perspectives. In particular, we are interested, but not limited to, in receiving contributions from the authors in the following areas:
1. Master regulators of hypoxia signaling in the kidney
2. Impact of hypoxia on normal renal function
3. Hypoxia, VEGF and Erythropoietin
4. Chronic hypoxia vs. intermittent hypoxia on renal function
5. High-altitude hypoxia and renal function
6. Renal hypoxia in cerebrovascular and cardiovascular complications
7. Exploring hypoxia signaling to manage anemia in CKD
Further, the risk factors associated with CKD evoke inappropriately low oxygen tension within the kidney. Systemic and intrarenal hypoxia is closely associated with fibrosis, inflammation, and CKD-related comorbidities such as sarcopenia, anemia, and cerebrovascular and cardiovascular events. Kidneys sense and respond to hypoxia, which is prevalent in extreme physiological or pathological conditions. The effect of hypoxia signaling on kidney function and injury is extensively investigated at the cellular and molecular levels. Adaptive and maladaptive responses by various parts of the kidney in response to hypoxia were extensively studied. Hypoxia signaling in the kidney is also explored therapeutically.
This collection aims to provide researchers, clinicians, and biologists with a state-of-the-art compilation of the activation of cellular and molecular responses to hypoxia in various kidney regions. This collection will provide a comprehensive understanding of the events that trigger in response to hypoxia and progress to varying degrees of kidney injury and presented with impaired kidney function. The intricate association of hypoxia with renal injury and maladaptive responses within the kidney will be reviewed. This article collection aims to provide data from in vitro experiments, experimental animals, clinical settings, and environmental conditions. This collection seeks to present the current and upcoming diagnostic and therapeutic approaches to combat hypoxia-associated CKD complications.
In this Research Topic, "Hypoxia Signaling and Renal Complications," we welcome contributions from researchers and clinicians exploring various aspects of hypoxia signaling in renal health and injury. We invite authors to submit original research articles, reviews, and perspectives. In particular, we are interested, but not limited to, in receiving contributions from the authors in the following areas:
1. Master regulators of hypoxia signaling in the kidney
2. Impact of hypoxia on normal renal function
3. Hypoxia, VEGF and Erythropoietin
4. Chronic hypoxia vs. intermittent hypoxia on renal function
5. High-altitude hypoxia and renal function
6. Renal hypoxia in cerebrovascular and cardiovascular complications
7. Exploring hypoxia signaling to manage anemia in CKD
Keywords: Kidney, hypoxia, CKD, Anemia, Fibrosis, Inflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
