This Research Topic is part of a series with:
https://www.frontiersin.org/research-topics/46543/new-insights-into-post-translational-modification-of-proteins-immune-regulation-in-carcinogenesis-heart-disease-neurodegenerative-disorders-and-allergic-diseases

Posttranslational modification (PTM) refers to the covalent chemical modifications of proteins after protein biosynthesis. PTM mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation, glycosylation, and ADP-ribosylation. PTM is crucial to the structure and function of the protein, and nearly affects all aspects of cell biology and pathogenesis. Identification and characterization of PTM to specific modifications on proteins are essential to discern the functional significance in biological contexts. On the other hand, innate and adaptive immune responses play a critical role in the development of human diseases. Immunotherapy has emerged as an attractive approach to treating complex diseases by activating the immune system.

In recent years, many findings have shown that PTMs are closely associated with immune regulation by
affecting immune cellular function and metabolic reprogramming. For instance, PTMs could promote PD-L1 mediated tumor immune escape by disrupting the protein stability to block the binding of PD-1 and PD-L1, thus promoting autoimmune responses. Given that PTM of immune factors is closely related to the pathogenesis and development of diseases such as cancer, cardiovascular, neurodegenerative disorders, and allergic diseases, targeting PTM of immune factors may be a valuable strategy to treat such diseases.

In this research topic, we welcome both original research articles and reviews that will address the significance of PTMs and immune regulation. We invite researchers to discuss the key molecular mechanisms as well as drug development in response to PTMs and/or immunity. A better understanding of such mechanisms may help identify new therapeutic targets for human complex diseases such as cancer, cardiovascular, neurodegenerative disorders, and allergic diseases, and therefore provide unique opportunities for drug discovery.

Potential topics include, but are not limited to:

• PTM-related mechanism in the pathogenesis of inflammatory immune diseases

• Development & discovery of inhibitors of immune checkpoints for treating immune diseases

• Drug discovery targeting PTMs of key proteins and the mechanism of action

• Experimental approaches for the identification of interplay of PTMs and immunogenicity

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Frontiers in Pharmacology

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