About this Research Topic
With the clinical pipeline of antibacterial drugs running dry, the development of additional novel drugs and strategies with unique target sites on the pathogens are paramount. The goal of this Research Topic is to collect together in one place the most recent and innovative aspects regarding the impact of Metal-Organic Frameworks in both current and future therapies. We believe the topics should showcase the main areas that are relevant for the design and implementation of inorganic materials in antibacterial therapies while concurrently contributing potential compounds as imminent leads for drug development. While impressive antibacterial properties were often reported, many challenges in terms of durability, sustainability, and efficiency in “real world” and clinical conditions remain. Therefore, special attention will be paid to modern synthesis methods to reduce side effects and limit the toxicity of inorganic materials in biomedical applications. This Research Topic is dedicated to original research and review papers of the highest quality that consider the synthesis and design of new antimicrobial inorganic materials (e.g., coatings, films, hydrogels, 3D systems) and/or their mechanism of action which significantly prevent the growth of or eradicate bacteria (planktonic or biofilm). While centred on materials science, contributions to this Research Topic are expected to have significant microbiological/clinical relevance.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Antibacterial/Antibiofilm activity and mechanisms of MOF-based composites
• MOFs-Metal/Metal Oxide Antibacterial Agents
• Textiles-embedded MOFs
• Health and medical indwelling devices coated/functionalized with MOFs
Keywords: Antimicrobial Materials, Micro/Nano-structured Antimicrobial Materials, Bactericidal Activity, Antimicrobial Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.