About this Research Topic
The gut microbiota is a complex microbial ecosystem that plays a critical role in regulating digestion, metabolism, and the bioactivity of nutrients. Dysbiosis of the gut microbiota leads to an excessive production of reactive oxygen species (ROS) in intestinal epithelial cells. This, in turn, increases oxidative stress and triggers inflammation, which are common pathological factors in obesity, metabolic syndrome, type 2 diabetes, and nervous system diseases.
Phenolics are a type of prebiotic that can promote the growth of probiotics while inhibiting the growth of pathogenic bacteria. In the colon, the gut microbiota biotransforms phenolics into phenolic derivatives, which have higher absorption and bioactivity. However, the specific bacteria responsible for this biotransformation process remain unclear, and the mechanisms through which phenolic metabolites and gut microbiota metabolites regulate human health have not been thoroughly elucidated. Microbiome studies are urgently needed in this field to provide new insights into targeting the gut microbiota for the prevention and treatment of chronic diseases.
This Research Topic aims to advance our understanding of the interaction between phenolics and gut microbiota, thus contributing to the prevention and treatment of chronic diseases. The scope of this topic includes, but is not limited to, the following areas:
· Profiling the metabolites of phenolics biotransformed by gut microbiota and evaluating the bioactivity of these metabolites in vivo.
· Investigating the preventive effects of phenolics and their metabolites on chronic diseases and exploring the underlying mechanisms.
· Exploring the role of phenolics as prebiotics and their potential in modulating the gut microbiota, gut barriers, and immune function.
· Designing novel delivery systems to enhance the activity and/or stability of phenolics, and targeting their release in the gastrointestinal tract.
Phenolics are a type of prebiotic that can promote the growth of probiotics while inhibiting the growth of pathogenic bacteria. In the colon, the gut microbiota biotransforms phenolics into phenolic derivatives, which have higher absorption and bioactivity. However, the specific bacteria responsible for this biotransformation process remain unclear, and the mechanisms through which phenolic metabolites and gut microbiota metabolites regulate human health have not been thoroughly elucidated. Microbiome studies are urgently needed in this field to provide new insights into targeting the gut microbiota for the prevention and treatment of chronic diseases.
This Research Topic aims to advance our understanding of the interaction between phenolics and gut microbiota, thus contributing to the prevention and treatment of chronic diseases. The scope of this topic includes, but is not limited to, the following areas:
· Profiling the metabolites of phenolics biotransformed by gut microbiota and evaluating the bioactivity of these metabolites in vivo.
· Investigating the preventive effects of phenolics and their metabolites on chronic diseases and exploring the underlying mechanisms.
· Exploring the role of phenolics as prebiotics and their potential in modulating the gut microbiota, gut barriers, and immune function.
· Designing novel delivery systems to enhance the activity and/or stability of phenolics, and targeting their release in the gastrointestinal tract.
Keywords: phenolics, gut microbiota, metabolites, delivery, chronic diseases
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