About this Research Topic
Osteoblasts' glycolytic activity is similar to the undifferentiated cells. There is also evidence from in vivo studies that more mature osteoblasts exhibit higher oxidative phosphorylation activity. Since the energy supply for mature osteoblasts depends on glycolysis, glycogenic amino acids constitute the raw material for the differentiated cells. The tricarboxylic acid cycle intermediates or pyruvic acid is produced during the metabolism of glycogenic amino acids, translocated to the mitochondria, and cause boosted expression of mRNA for the enzymes alkaline phosphatase, runt-related transcription factor 2 (Runx2), and osteocalcin, which are involved in osteogenesis.
Since there is evidence that the biophysical stimulation, at the distinct parametric range, affects the maturation of osteoblasts the interrelation between external biophysical stimulation and the buildup of mitochondrial transmembrane potential might exist and should be further investigated.
Research on the pathways from biophysical stimulation of osteoblast to osteoblast synthetic activity via involvement of mitochondrial machinery might reveal a new aspect of bone regeneration stimulation that currently hasn't been reported to a large extent. Such reports might be a basis for future innovative clinical methods for bone regeneration.
Since there is evidence that the biophysical stimulation, at the distinct parametric range, affects the maturation of osteoblasts the interrelation between external biophysical stimulation and the buildup of mitochondrial transmembrane potential might exist and should be further investigated.
Research on the pathways from biophysical stimulation of osteoblast to osteoblast synthetic activity via involvement of mitochondrial machinery might reveal a new aspect of bone regeneration stimulation that currently hasn't been reported to a large extent. Such reports might be a basis for future innovative clinical methods for bone regeneration.
Keywords: osteoblast, mitochondria, aerobic glycolysis, mitochondrial transmembrane potential, mitochondrial permeability transition pore, bone regeneration
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