The field of Papillomaviruses (PVs) infection in animals is a significant area of study due to its role in causing skin, genital, and perianal benign and malignant lesions, as well as other malignancies in different squamous epithelia. Persistent infection, viral DNA integration, and the constitutive expression of PVs oncoproteins can lead to cancer development and progression. While the immune system typically clears the virus, some infections persist, causing a range of dysplastic changes from benign proliferations to premalignant lesions at risk of cancer progression. Current research has identified some genetic and epigenetic changes and complex molecular networks in PV-related cancers, but a comprehensive overview of ongoing research is still missing. Furthermore, PVs provide valuable models for vaccination against human papillomavirus (HPV), offering applicable information for HPV.
This research topic aims to shed light on the pathogenesis of different PV infections in various species, particularly the processes promoting tumorigenesis and tumor progression towards malignancy. The goal is to bring together expert opinions and new advances from across the field, providing a comprehensive understanding of PVs characterization, mechanisms contributing to PVs-induced carcinogenesis, and potential therapeutic opportunities.
To gather further insights into the range and limitations of PV infections in different species, we welcome articles addressing, but not limited to, the following themes:
- The role of oncoviral proteins in cell transformation
- The gene mutational profile of viral and host interactions
- Changes in protein expression of tumor cells after PV infection
- Immune response to PV infection
- Clinical behavior and development of related diseases
- Therapeutic opportunities, including vaccines for PVs-related cancers.
Keywords:
neoplasia, pathogenesis, virus/host interactions, animal models, papillomavirus
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The field of Papillomaviruses (PVs) infection in animals is a significant area of study due to its role in causing skin, genital, and perianal benign and malignant lesions, as well as other malignancies in different squamous epithelia. Persistent infection, viral DNA integration, and the constitutive expression of PVs oncoproteins can lead to cancer development and progression. While the immune system typically clears the virus, some infections persist, causing a range of dysplastic changes from benign proliferations to premalignant lesions at risk of cancer progression. Current research has identified some genetic and epigenetic changes and complex molecular networks in PV-related cancers, but a comprehensive overview of ongoing research is still missing. Furthermore, PVs provide valuable models for vaccination against human papillomavirus (HPV), offering applicable information for HPV.
This research topic aims to shed light on the pathogenesis of different PV infections in various species, particularly the processes promoting tumorigenesis and tumor progression towards malignancy. The goal is to bring together expert opinions and new advances from across the field, providing a comprehensive understanding of PVs characterization, mechanisms contributing to PVs-induced carcinogenesis, and potential therapeutic opportunities.
To gather further insights into the range and limitations of PV infections in different species, we welcome articles addressing, but not limited to, the following themes:
- The role of oncoviral proteins in cell transformation
- The gene mutational profile of viral and host interactions
- Changes in protein expression of tumor cells after PV infection
- Immune response to PV infection
- Clinical behavior and development of related diseases
- Therapeutic opportunities, including vaccines for PVs-related cancers.
Keywords:
neoplasia, pathogenesis, virus/host interactions, animal models, papillomavirus
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.