Genomic Dissection and Therapy Development in Liver Cancer

Hepatocellular carcinoma (HCC), constituting approximately 90% of primary liver cancer cases, emerges within the context of chronic inflammation and a spectrum of driver gene mutations. The genomic landscape of HCC exhibits substantial heterogeneity, resulting in distinct gene expression patterns, immune landscapes, and responses to chemotherapy or immunotherapy. This intrinsic variability contributes significantly to the challenges faced in achieving successful chemotherapy or immunotherapy outcomes in a considerable proportion of HCC patients. Hence, there is an urgent need for a comprehensive dissection of genomic subtypes and the development of precise therapeutic interventions for HCC.

This Research Topic is dedicated to unraveling the molecular and clinical intricacies of HCC across diverse genomic backgrounds, with a focus on proposing innovative therapeutic strategies. We invite submissions of Original Research, Reviews, and Mini-reviews, covering subtopics including but not limited to the following:
• Uncovering and characterizing novel genomic subtypes of HCC.
• Investigating the molecular and clinical features associated with distinct genomic backgrounds in HCC.
• Establishing advanced HCC mouse models reflective of different genomic backgrounds.
• Identifying novel mechanisms governing the initiation and progression of HCC across diverse genomic contexts.
• Crafting potential therapeutic strategies tailored to HCC with varied genomic backgrounds.

Keywords: Hepatocellular carcinoma, Genomic diversity, Driver gene mutations, Chemotherapy, Immunotherapy

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.