About this Research Topic
Effects of abnormal morphology and dysfunction of mitochondria on immune microenvironment.
Mitochondria lie at the heart of immunity that are known as the powerhouses of immunity. They not only affect the activation, proliferation and differentiation of immune cells, but also induce the expression of genes involved in antigen presentation. There are many studies to interpret the close links between mitochondria and immune microenvironment but relevant mechanisms are still unclear. Thus, the goal of this Research Topic is to explore how the alterations of mitochondrial morphology and function in various chronic diseases affect the course of illness and the immunological mechanism behind it so that we can target mitochondria to find a tantalizing array of therapeutic possibilities for inflammatory diseases and cancer.
We welcome submissions of Original Research, Review, Mini-review, Case Report, Opinion and Methods articles that address, but are not limited to, the following subtopics:
1) Effects of alterations of TCA cycle metabolites, oxidative stress and calcium homeostasis on immune microenvironment.
2) Role of mitochondria quality control mechanisms (mitochondrial fusion, fission and mitophagy) in regulating immune microenvironment and immune functions.
3) The mechanism of disease occurrence and development caused by abnormal morphology and function of mitochondria in immune cells.
4) Effects of mito-protective drugs on immune microenvironment.
5) The immunoregulatory efficacy of mitochondrial transplantation in disease intervention.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Mitochondria lie at the heart of immunity that are known as the powerhouses of immunity. They not only affect the activation, proliferation and differentiation of immune cells, but also induce the expression of genes involved in antigen presentation. There are many studies to interpret the close links between mitochondria and immune microenvironment but relevant mechanisms are still unclear. Thus, the goal of this Research Topic is to explore how the alterations of mitochondrial morphology and function in various chronic diseases affect the course of illness and the immunological mechanism behind it so that we can target mitochondria to find a tantalizing array of therapeutic possibilities for inflammatory diseases and cancer.
We welcome submissions of Original Research, Review, Mini-review, Case Report, Opinion and Methods articles that address, but are not limited to, the following subtopics:
1) Effects of alterations of TCA cycle metabolites, oxidative stress and calcium homeostasis on immune microenvironment.
2) Role of mitochondria quality control mechanisms (mitochondrial fusion, fission and mitophagy) in regulating immune microenvironment and immune functions.
3) The mechanism of disease occurrence and development caused by abnormal morphology and function of mitochondria in immune cells.
4) Effects of mito-protective drugs on immune microenvironment.
5) The immunoregulatory efficacy of mitochondrial transplantation in disease intervention.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Mitochondria, Mitochondria quality control, Immune microenvironment, Immune function, Mitochondrial transplantation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
