Neurodegenerative diseases such as Alzheimer's, Parkinson's, Frontotemporal Dementia (FTD), and Multiple Sclerosis (MS) pose formidable challenges to healthcare due to their complexity and the diverse mechanisms driving their progression. Although changes in certain highly affected cell types for each disease, such as dopaminergic neurons in Parkinson’s, have been extensively studied, there exists a significant void in our understanding of other vital brain cell populations like endothelial and ependymal cells. The emergence of multi-omics technologies, integrating transcriptomics, proteomics, and metabolomics, offers an unprecedented opportunity for holistic cellular profiling. These methodologies enable a comprehensive examination of molecular alterations associated with neurodegenerative conditions. Nevertheless, their application to understudied brain cell types in the context of these diseases remains scant, highlighting a crucial area of research that demands attention.
This Research Topic is crucial as it seeks to address the existing knowledge void by concentrating on the understudied brain cell types in neurodegenerative diseases, using advanced multi-omics methodologies. By leveraging recent advancements in transcriptomics (including bulk, single-cell, and single-nucleus RNAseq), proteomics (both bulk and single-cell), and metabolomics (e.g., lipidomics), we aim to elucidate the changes in RNA, protein expression, and metabolism in these overlooked cell populations. This approach is expected to reveal novel insights into the cellular mechanisms of diseases such as Alzheimer’s, Parkinson’s, FTD, and MS. The primary objective is to uncover new therapeutic targets and pathways, which could be instrumental in developing innovative treatments. Furthermore, this initiative will encourage validation of these targets in mouse models, thereby facilitating translational research and potentially leading to groundbreaking advancements in therapeutics for neurodegenerative diseases.
We invite authors to submit original research, review articles, and method papers that employ multi-omics strategies to investigate the less studied brain cell types in neurodegenerative diseases. Contributions should emphasize the relevance of the findings to the overall understanding of these diseases and their potential in therapeutic development. We encourage submissions that utilize a combination of transcriptomics, proteomics, and metabolomics methodologies and that integrate these data to provide comprehensive insights. Papers that explore the implications of these findings for the identification of novel therapeutic targets and pathways are particularly welcome. Additionally, studies that validate findings using animal models will be highly regarded. Authors should strive to present innovative methodologies, integrate various omics approaches, and provide thorough discussions on how their findings can contribute to the development of new treatment strategies.
Keywords:
Multi-Omics, Neurodegenerative Diseases, Understudied Brain Cell Types, Astrocytes, Oligodendrocytes, Novel Therapeutic Targets, Advanced Methodologies, Translational Research.
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Neurodegenerative diseases such as Alzheimer's, Parkinson's, Frontotemporal Dementia (FTD), and Multiple Sclerosis (MS) pose formidable challenges to healthcare due to their complexity and the diverse mechanisms driving their progression. Although changes in certain highly affected cell types for each disease, such as dopaminergic neurons in Parkinson’s, have been extensively studied, there exists a significant void in our understanding of other vital brain cell populations like endothelial and ependymal cells. The emergence of multi-omics technologies, integrating transcriptomics, proteomics, and metabolomics, offers an unprecedented opportunity for holistic cellular profiling. These methodologies enable a comprehensive examination of molecular alterations associated with neurodegenerative conditions. Nevertheless, their application to understudied brain cell types in the context of these diseases remains scant, highlighting a crucial area of research that demands attention.
This Research Topic is crucial as it seeks to address the existing knowledge void by concentrating on the understudied brain cell types in neurodegenerative diseases, using advanced multi-omics methodologies. By leveraging recent advancements in transcriptomics (including bulk, single-cell, and single-nucleus RNAseq), proteomics (both bulk and single-cell), and metabolomics (e.g., lipidomics), we aim to elucidate the changes in RNA, protein expression, and metabolism in these overlooked cell populations. This approach is expected to reveal novel insights into the cellular mechanisms of diseases such as Alzheimer’s, Parkinson’s, FTD, and MS. The primary objective is to uncover new therapeutic targets and pathways, which could be instrumental in developing innovative treatments. Furthermore, this initiative will encourage validation of these targets in mouse models, thereby facilitating translational research and potentially leading to groundbreaking advancements in therapeutics for neurodegenerative diseases.
We invite authors to submit original research, review articles, and method papers that employ multi-omics strategies to investigate the less studied brain cell types in neurodegenerative diseases. Contributions should emphasize the relevance of the findings to the overall understanding of these diseases and their potential in therapeutic development. We encourage submissions that utilize a combination of transcriptomics, proteomics, and metabolomics methodologies and that integrate these data to provide comprehensive insights. Papers that explore the implications of these findings for the identification of novel therapeutic targets and pathways are particularly welcome. Additionally, studies that validate findings using animal models will be highly regarded. Authors should strive to present innovative methodologies, integrate various omics approaches, and provide thorough discussions on how their findings can contribute to the development of new treatment strategies.
Keywords:
Multi-Omics, Neurodegenerative Diseases, Understudied Brain Cell Types, Astrocytes, Oligodendrocytes, Novel Therapeutic Targets, Advanced Methodologies, Translational Research.
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.