Traumatic Brain Injury (TBI) is a major global health concern, with millions of people affected annually. It results from a sudden, external force applied to the head, often due to accidents, falls, sports injuries, or military combat. While immediate physical symptoms and cognitive deficits may improve over time, a growing body of research has shown that TBI can lead to persistent neurodegenerative processes and cognitive impairment that can persist for years or even decades after the initial injury. Despite the growing recognition of the link between TBI and neurodegeneration, many questions remain unanswered. Understanding the specific mechanisms underlying post-TBI neurodegeneration, identifying biomarkers for early detection, and developing effective interventions to prevent or slow down the progression of cognitive decline are areas of ongoing research and clinical interest.

Recent research has brought to light several groundbreaking advances in the field of TBI-related neurodegeneration and cognitive impairment. These studies have indicated critical facets, including the pivotal roles played by neuroinflammation, tau protein pathology, intracranial lymphatic system-mediated waste clearance and novel imaging techniques in TBI-related neurodegeneration, presenting opportunities for progress. These advances have significantly deepened our understanding of the underlying mechanisms and potential therapeutic targets. The goal of this topic is to address the pressing problem of neurodegeneration and cognitive impairment following traumatic brain injury (TBI) by elucidating the underlying mechanisms and exploring recent advances in diagnosis, treatment, and prevention.

This research topic welcomes but not limited to the following scopes:

- Neurobiological Mechanisms: Articles in this category should delve into the underlying neurobiological mechanisms that contribute to neurodegeneration after TBI. This may include studies on axonal injury, neuroinflammation, oxidative stress, and protein aggregation.

- Neuroimaging and Biomarkers: Contributions focused on advanced neuroimaging techniques and potential biomarkers for assessing neurodegeneration and cognitive decline in TBI patients are highly encouraged. This section will provide insights into early diagnosis and monitoring.

- Clinical Outcomes: Research articles, clinical trials, and case studies discussing the long-term clinical outcomes of individuals with TBI, with a particular focus on cognitive impairment, dementia, and other neurodegenerative conditions.

- Neuroprotective Strategies: Exploration of neuroprotective interventions and therapeutic approaches aimed at mitigating or preventing neurodegeneration following TBI. This could encompass pharmacological, rehabilitative, and lifestyle-based interventions.

- Patient Perspectives: Qualitative and quantitative studies examining the lived experiences of individuals with TBI-related cognitive impairment, including their challenges, coping mechanisms, and needs.

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Frontiers in Neuroscience

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