About this Research Topic
Acute respiratory failure (ARF) is a critical condition that often necessitates the use of mechanical ventilation (MV) in intensive care units worldwide. MV serves as a crucial intervention to maintain adequate gas exchange and protect the lungs, despite its inherent side effects. Over the years, the adverse effects of MV on the lungs have been extensively studied, leading to the development of concepts such as ventilator-induced lung injury (VILI) and patient self-inflicted lung injury (P-SILI). However, the systemic effects of MV, beyond the lungs, have not been thoroughly explored. Questions remain regarding the impact of MV on other organs and systems, such as the kidneys, fluid balance, and electrolytes, and their significance in clinical settings. Addressing these gaps is essential for improving patient outcomes and understanding the broader implications of MV in ARF management.
This Research Topic aims to provide a comprehensive exploration of the systemic effects of MV in patients with acute respiratory failure. By examining the cross-talk between the lungs and other organ systems during MV, the research seeks to uncover the molecular, physiological, anatomical, and clinical interactions that occur. The goal is to enhance our understanding of how MV influences not only the lungs but also the entire body, ultimately leading to improved clinical outcomes for ARF patients.
To gather further insights into the systemic effects of MV in ARF patients, we welcome Brief Research Report, Clinical Trial, General Commentary, Hypothesis & Theory, Mini Review, Original Research, Perspective, Review and Systematic Review articles addressing, but not limited to, the following themes:
• Brain interactions and neurological implications
• Gut and microbiota responses
• Cardiovascular effects and hemodynamic changes
• Immune system modulation
• Renal function and fluid-electrolyte balance
• Hepatic responses and liver function
• Lung-machine cross-talk, including the impact of various respiratory support techniques such as invasive and non-invasive mechanical ventilation, extracorporeal membrane oxygenation, and extracorporeal carbon dioxide removal.
This Research Topic aims to provide a comprehensive exploration of the systemic effects of MV in patients with acute respiratory failure. By examining the cross-talk between the lungs and other organ systems during MV, the research seeks to uncover the molecular, physiological, anatomical, and clinical interactions that occur. The goal is to enhance our understanding of how MV influences not only the lungs but also the entire body, ultimately leading to improved clinical outcomes for ARF patients.
To gather further insights into the systemic effects of MV in ARF patients, we welcome Brief Research Report, Clinical Trial, General Commentary, Hypothesis & Theory, Mini Review, Original Research, Perspective, Review and Systematic Review articles addressing, but not limited to, the following themes:
• Brain interactions and neurological implications
• Gut and microbiota responses
• Cardiovascular effects and hemodynamic changes
• Immune system modulation
• Renal function and fluid-electrolyte balance
• Hepatic responses and liver function
• Lung-machine cross-talk, including the impact of various respiratory support techniques such as invasive and non-invasive mechanical ventilation, extracorporeal membrane oxygenation, and extracorporeal carbon dioxide removal.
Keywords: Lung cross-talk, mechanical ventilation, positive pressure ventilation impact, multiple organ support, lung-kidney cross-talk, lung-liver cross-talk, lung machine cross-talk
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
