About this Research Topic
The trillions of microorganisms staying in the gut, collectively termed the gut microbiome, play crucial roles in our well-being. The gut microbiome is involved in digestion and nutrient metabolism, immune system development and function. On the other hand, microbial dysbiosis refers to an imbalance or disruption in the composition and/or function of the gut microbiota. Dysbiosis can compromise the integrity of the intestinal barrier, leading to increased intestinal permeability, triggering inflammation and immune responses that can contribute to various gut disorders and systemic health problems. Fecal microbiota transplantation (FMT) has shown promising implications in the treatment associated with dysbiosis. It is an intervention that involves transferring fecal material from a healthy donor to a diseased recipient to restore a balanced gut microbiota composition and promote a better immune response. FMT is showed promising aspects in recurrent Clostridium difficile infection (rCDI), inflammatory bowel disease (IBD), non-alcoholic fatty liver disease, neurological disorders and even in cancer treatment, particularly its potential implications in immunotherapy. Along with humans, FMT is also successfully used in the livestock industry, especially in intractable calf diarrhoea treatment.
There is still much to learn about the microbiome and its role in fighting disease using FMT. As research in this field continues to advance, a deeper understanding of the FMT mechanism will allow us to develop a targeted, personalized therapy. Thus, the goal of this special issue is to gather knowledge on the latest research based on FMT, which may shed light on crucial aspects of FMT such as standardizing donor screening protocols, best donor selection, ensuring safety in the transfer of microbiota, determining optimal delivery methods, and ensuring the long-term safety of FMT.
Overall, this issue will help us to translate the FMT knowledge that can be utilized for considering FMT to be used for clinical practices regularly.
There is still much to learn about the microbiome and its role in fighting disease using FMT. As research in this field continues to advance, a deeper understanding of the FMT mechanism will allow us to develop a targeted, personalized therapy. Thus, the goal of this special issue is to gather knowledge on the latest research based on FMT, which may shed light on crucial aspects of FMT such as standardizing donor screening protocols, best donor selection, ensuring safety in the transfer of microbiota, determining optimal delivery methods, and ensuring the long-term safety of FMT.
Overall, this issue will help us to translate the FMT knowledge that can be utilized for considering FMT to be used for clinical practices regularly.
Keywords: Fecal microbiota transplantation; FMT; Intestinal microbiota; microbial dysbiosis; IBD; Immune response
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
