About this Research Topic
The gut microbiome, a complex ecosystem of microorganisms inhabiting the gastrointestinal tract, plays a crucial role in maintaining host health and disease. Early-life gut microbiota perturbations have been increasingly recognized as influential factors that can have profound and lasting effects on the host's physiological and metabolic development. This field of research intersects microbiology, developmental biology, and health sciences, offering a unique perspective on the intricate interplay between microbial communities and the host organism. This Research Topic aims to explore the relationship between early-life gut microbiota perturbations and their enduring consequences on host health. Recent advances in microbiome research are starting to shed light on the underlying mechanisms through which quali-quantitative reassortment of microbial communities during critical developmental periods can impact immune function, metabolism, and neurological and endocrine outcomes. Several pregnancy (e.g. pharmacological treatments, antibiotic use, infection, malnutrition) and/or very early-life exposures (e.g. type of delivery, stressful environments, antibiotic use) have been associated with alteration of the offspring microbiome and development or predisposition to disease in childhood and adulthood.
The goal of this special issue is to elucidate mechanisms and identify therapeutic opportunities that leverage the gut microbiota to promote health and prevent disease. By bringing together multidisciplinary insights, we aim to address critical gaps in our understanding and pave the way for innovative interventions.
We welcome perspectives, reviews, original research articles, and methodologies contributing to a comprehensive understanding of this dynamic interplay. Authors are encouraged to explore and discuss potential therapeutic opportunities arising from their research findings. Together, we aim to advance the field and unlock the full potential of early-life gut microbiota modulation for promoting host health and well-being.
We invite contributions from researchers exploring various facets of early-life gut microbiota perturbations and their impacts on host health. Topics of interest include, but are not limited to:
• Molecular mechanisms underlying the crosstalk between early-life gut microbiota and host development
• High throughput and targeted analyses of epigenetic and gene expression profiles upon early-life microbiota perturbation.
• Immunological consequences of perturbed gut microbiota during critical developmental stages.
• Neurological outcomes associated with alterations in the early-life gut microbiome.
• Therapeutic interventions also including microbiota-based approaches targeting the gut microbiota to mitigate long-term health consequences.
• Innovative methodologies for studying the composition and function of the early-life gut microbiota.
• The impact of different early-life nutrition patterns into the influence of the composition and function of the gut microbiota.
• The impact of environmental factors such as exposure to pollutants, urbanization, and lifestyle choices on the establishment and stability of the early-life gut microbiome.
• Emerging prognostic and diagnostic tools and techniques for assessing the early-life gut microbiota status and predicting potential health outcomes.
The goal of this special issue is to elucidate mechanisms and identify therapeutic opportunities that leverage the gut microbiota to promote health and prevent disease. By bringing together multidisciplinary insights, we aim to address critical gaps in our understanding and pave the way for innovative interventions.
We welcome perspectives, reviews, original research articles, and methodologies contributing to a comprehensive understanding of this dynamic interplay. Authors are encouraged to explore and discuss potential therapeutic opportunities arising from their research findings. Together, we aim to advance the field and unlock the full potential of early-life gut microbiota modulation for promoting host health and well-being.
We invite contributions from researchers exploring various facets of early-life gut microbiota perturbations and their impacts on host health. Topics of interest include, but are not limited to:
• Molecular mechanisms underlying the crosstalk between early-life gut microbiota and host development
• High throughput and targeted analyses of epigenetic and gene expression profiles upon early-life microbiota perturbation.
• Immunological consequences of perturbed gut microbiota during critical developmental stages.
• Neurological outcomes associated with alterations in the early-life gut microbiome.
• Therapeutic interventions also including microbiota-based approaches targeting the gut microbiota to mitigate long-term health consequences.
• Innovative methodologies for studying the composition and function of the early-life gut microbiota.
• The impact of different early-life nutrition patterns into the influence of the composition and function of the gut microbiota.
• The impact of environmental factors such as exposure to pollutants, urbanization, and lifestyle choices on the establishment and stability of the early-life gut microbiome.
• Emerging prognostic and diagnostic tools and techniques for assessing the early-life gut microbiota status and predicting potential health outcomes.
Keywords: gut microbiome, early-life gut microbiota perturbation, gut microbiome-host interaction, immune system development, gene expression profiles, epigenetic profiles, gut microbiota and neuromodulation, therapeutic interventions, early-life nutrition, prognostic and diagnostic biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
