This Research Topic is part of the Methods and Applications in series.

Cellular neurobiology is a rapidly evolving field that seeks to unravel the complexities of the nervous system at the cellular level. Despite significant advancements, there remain critical gaps in our understanding of the cellular mechanisms underlying both normal and pathological conditions of the nervous system. Current research is focused on elucidating the physiological and pathological mechanisms of cellular damage in various disease models, including degenerative, ischemic, traumatic, inflammatory conditions, and cancer. Recent studies have employed a range of experimental techniques, from genetic engineering to pharmacological and surgical methods, to model these conditions and study the underlying neuro-mechanisms. However, there is a pressing need for improved and novel methodologies that can provide deeper insights into these processes, particularly at the molecular, subcellular, cellular, and microcircuit levels. This research topic aims to address these gaps by highlighting the latest experimental techniques and methods used in cellular neuroscience research.

This collection aims to collect new evidence and perspectives on the nervous system in both pathological and normal conditions. The primary objective is to explore the advantages and limitations of current experimental techniques and to advance our understanding of the physiological and pathological mechanisms of cellular damage. Specific questions include how different methods can be adapted or improved for specific research purposes and what new insights can be gained from these methodologies. The research will also test hypotheses related to the effectiveness and utility of various experimental techniques in cellular neurobiology.

To gather further insights in cellular neurobiology research, we welcome articles addressing, but not limited to, the following themes:

- Development and validation of new or improved experimental methods.
- Detailed protocols with troubleshooting tips for cellular neurobiology research.
- Reviews and mini-reviews on current and emerging techniques in the field.
- Perspectives on the future directions of cellular neurobiology methodologies.
- Original research on physiological and pathological mechanisms in the developing and aging brain.
- Studies on the molecular, subcellular, cellular, and microcircuit levels of neuro-mechanisms.

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Frontiers in Cellular Neuroscience

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